Molecular-genetic markers are the most important prognostic factors of B-cell chronic lymphocytic leukemia (B-CLL). These markers are VH mutational status, it’s surrogate markers — СD38, ZAP-70, LPL и ADAM29 and the aim of this study - cytogenetic abnormalities. We have hold cytogenetic research of blood, bone marrow and lymph nodes cells of 135 non-treated patients.

We recognized several cytogenetic features of the B-CLL form, which characterizes by massive peripheral, thoracic, and abdominal lym-phadenopathy and not large leucocytes counts. 11q23 deletion is defined in most of such cases, trisomy 12 — significantly more often than in other B-CLL forms, and del13q14 is never revealed in patients with this B-CLL form, though it is the most frequent aberration in B-CLL. We divided all B-CLL cases in three prognostic groups: favorable group are the patients without cytogenetic aberrations or with del13q14 as the single chromosome abnormality; the group of intermediate prognosis are the patients with trisomy 12, and also the patients with del11q23, which is traditionally divided to unfavorable prognostic factors; unfavorable group are the patients with del17p13 or complex abnormalities of karyotype.

Cytogenetic study helps to define the prognosis of B-CLL and to reveal the patients of «risk group», who need the early treatment.

This is a case report of the 64-year-old male patient who suffered of previously untreated chronic lymphocytic leukemia (CLL), and paraneoplastic pemphigus. He was treated with prednisolone, MabThera, chlorambucil and cyclophosphamide. The patient achieved remission of CLL, and all symptoms of paraneoplastic pemphigus disappeared. During the year after the treatment he has good performance status, and receives only low doses of chlorambucil and prednisolone.

Between July 2005and October 2006, eight patients (pts) with hairy cell leukaemia were treated with Vero- cladribine at N.N. Blokhin Cancer Research Center. All pts achieved complete remission (CR). Duration of CR ranges from 1+ to 12+ months in 7 cases. There were no serious adverse events during the treatment and follow-up periods (1-12 months). Vero- cladribine was well tolerated. Anemia (grade IV) was seen in 1 patient and thrombocytopenia (grade I) was seen in another 1 patient. No one patient has febrile neutropenia or infectious complication.

Campath is a humanized monoclonal antibody targeted to the CD52 antigen. It shows efficacy with response rate of 35% in treatment of patients with chronic lymphocytic leukemia (CLL) who were refractory to fludarabine. A first-line therapy with Campath demonstrates efficacy in more than 80% of CLL patients. Campath deserves a special emphasis due to effectiveness in different autoimmune cytope-nias. We describe 2 cases of CLL and autoimmune thrombocytopenia, treated with Campath. Both patients received 36 infusions of Campath. There were no severe leucopenia or anemia as well as serious infections. Stable platelet count recovery, no evidence of antiplatelet antibodies and elimination of bone marrow lymphoid infiltration were achieved after the end of the treatment.

This article demonstrates case report and review of literature of successful use Campath in combination with total skin electron beam irradiation in mycosis fungoides.

We report results of therapy with recombinant human erythropoietin alpha (Eprex) in patients (pts) with multiple myeloma and chronic lymphocytic leukaemia during chemotherapy. 14pts were included in this study. A level of endogenous erythropoietin, a serum iron binding capacity, and a level of serum iron were evaluated before the start of treatment. Oral iron medication prescribes in cases of established iron deficiency. A rate of increase of hemoglobin level was monitored on week 4, 8, and 12. Objective effect was achieved in 12 (85,7%) pts on 12-th week of treatment. Normal and moderately increased endogenous erythropoietin level was not a negative predicted factor for Eprex efficacy. We did not reveal complications of study drug. Therapy was executed in out-patient treatment regimen. We documented decrease of hospitalization necessity and transfusion dependence. An important treatment outcome resulted in improving of quality of life.