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Molecular genetic abnormalities in patients with T-cell acute lymphoblastic leukemia: a literature review

https://doi.org/10.17650/1818-8346-2022-17-4-166-176

Abstract

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive hematological disease. Modern polychemotherapy protocols allow achieving a 5-year overall survival of 60–90 % in different age groups, however, relapses and refractory forms of T-ALL remain incurable. Over the past decades, the pathogenesis of this variant of leukemia has been studied in many trials, and it has been found that various signaling pathways are involved in the multi-step process of leukemogenesis. This opens the way for targeted therapy.
In this review, we provide an update on the pathogenesis of T-ALL, opportunities for introducing targeted therapies, and issues that remain to be addressed.

About the Authors

A. N. Vasileva
National Research Center for Hematology, Ministry of Health of Russia
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167


O. A. Aleshina
National Research Center for Hematology, Ministry of Health of Russia
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167


B. V. Biderman
National Research Center for Hematology, Ministry of Health of Russia
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167


A. B. Sudarikov
National Research Center for Hematology, Ministry of Health of Russia
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167


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For citations:

Vasileva A.N., Aleshina O.A., Biderman B.V., Sudarikov A.B. Molecular genetic abnormalities in patients with T-cell acute lymphoblastic leukemia: a literature review. Oncohematology. 2022;17(4):166-176. (In Russ.) https://doi.org/10.17650/1818-8346-2022-17-4-166-176

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