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Frequency of red cell, leukocytic and platelet alloantibodies in patients with hematological diseases

https://doi.org/10.17650/1818-8346-2013-8-4-13-17

Abstract

History of multiple transfusions in patients with hematological diseases increases the likelihood of immunization to donor blood cells antigens
and immunological complications development. Incidence of alloantibodies development in this patients was assessed in this work. Alloantibodies detection was performed in patients with aplastic anemia, acute leukemia, chronic lymphocytic leukemia, and autoimmune thrombocytopenia. 9696 patients were included in this study. Frequency of alloantibodies to red cell antigens was 3.8 %, with 0.9 % of the antibody belong to the immunoglobulin G, and 2.9 % of the cases – to immunoglobulin M. Most of the IgG antibodies had following specificity:
monospecific anti-D antibody (21 cases), anti-DC and anti-DE antibodies (4 cases), anti-C (8 cases), anti-E (15), anti-c (13), and anti-K (11). Anti-e (1), anti-Fya (2), anti-Lea (4), anti-S (2), anti-s (2), anti-Jka (2) antibodies were less common. Granulocytes antibodies were found in 66.7 % of 384 patients, with results dependent on the detection method used. The presence of antiplatelet alloantibodies studied in 285 serum samples, of which antibodies were detected in 99 patients (34.7 %). Specificity of platelet antibodies was determined in three serum samples only: anti-2b, anti-1a, anti-1b. In other patients, probably present antibodies to several antigens simultaneously, and to identify them was not possible.

About the Authors

N. V. Mineeva
Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological Agency
Russian Federation


S. V. Gavrovskaya
Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological Agency
Russian Federation


I. I. Krobinets
Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological Agency
Russian Federation


I. A. Pashkova
Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological Agency
Russian Federation


N. N. Bodrova
Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological Agency
Russian Federation


E. A. Sysoeva
Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological Agency
Russian Federation


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Review

For citations:


Mineeva N.V., Gavrovskaya S.V., Krobinets I.I., Pashkova I.A., Bodrova N.N., Sysoeva E.A. Frequency of red cell, leukocytic and platelet alloantibodies in patients with hematological diseases. Oncohematology. 2013;8(4):13-17. (In Russ.) https://doi.org/10.17650/1818-8346-2013-8-4-13-17

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ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)