Гонадотоксичность терапии лимфомы Ходжкина у подростков и молодых мужчин: актуальность проблемы и пути решения (обзор литературы)
Аннотация
В настоящее время лимфома Ходжкина (ЛХ) – одно из наиболее курабельных опухолевых заболеваний, при этом более половины заболевших являются лицами мужского пола в возрасте до 35 лет. Гонадотоксичность служит одним из наиболее частых отдаленных последствий терапии ЛХ, что ассоциировано со значительным ухудшением качества жизни больных. В настоящей статье обобщены данные о частоте встречаемости и факторах риска развития гонадотоксичности у лиц мужского пола с ЛХ. Показано, что проведение химиотерапии с включением алкилирующих препаратов и лучевая терапия могут приводить к развитию гонадотоксичности у значительного числа больных. Рассмотрены современные возможности проведения криоконсервации спермы до начала противоопухолевой терапии.
Об авторах
А. А. Винокуров
ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии
Минздравсоцразвития России
Россия
Россия
С. Р. Варфоломеева
ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии
Минздравсоцразвития России
Россия
Россия
Д. И. Тарусин
Научно-практический центр детской и подростковой андрологии Департамента здравоохранения города Москвы
Россия
Россия
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Для цитирования:
Винокуров А.А., Варфоломеева С.Р., Тарусин Д.И. Гонадотоксичность терапии лимфомы Ходжкина у подростков и молодых мужчин: актуальность проблемы и пути решения (обзор литературы). Онкогематология. 2011;6(2):12-18. https://doi.org/10.17650/1818-8346-2011-6-2-12-18
For citation:
Vinokurov A.A., Varfolomeeva S.R., Tarusin D.I. Gonadal toxicity of Hodgkin lymphoma treatment in adolescents and young males: issue relevance and ways of solve (literature review). Oncohematology. 2011;6(2):12-18. (In Russ.) https://doi.org/10.17650/1818-8346-2011-6-2-12-18
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