Persistence of a new coronavirus infection in a patient with primary central nervous system large B-cell lymphoma with assessment of the humoral immune response against SARS-CoV-2

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Abstract

Treatment of immunocompromised patients with novel coronavirus infection (COVID-19) presents significant challenges. Currently, there are no unified approaches to the treatment of persistent COVID-19 in hematological malignancies. There is a need to develop recommendations for the management of such patients, chemotherapy protocols, as well as therapy for COVID-19 in case of SARS-CoV-2 virus persistence. Doctors are faced with cases of virus persistence, clinical manifestations during a long course of the infectious process and are not provided with methodological recommendations for patient supervision. As scientific data on the persistent COVID-19 course in patients with lymphoproliferative diseases accumulates, it is planned to create recommendations for the treatment of COVID-19 for patients in this group. This article describes a clinical case of persistent COVID-19 course in a comorbid patient with primary central nervous system large B-cell lymphoma during chemotherapy.

About the authors

Yu. Yu. Polyakov

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Author for correspondence.
Email: yurij.polyakov86@yandex.ru
ORCID iD: 0009-0007-8389-6269

Yuriy Yu. Polyakov.

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. A. Baryakh

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

ORCID iD: 0000-0001-6880-9269

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991; Build. 1, 2/1 Barrikadnaya St., Moscow 125993

Russian Federation

E. N. Misyurina

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0003-2419-4850

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. I. Zhelnova

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-0343-9348

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

M. A. Mingalimov

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-8491-2140

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

S. A. Kardovskaya

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0000-0002-4220-7582

3 Pekhotnaya St., Moscow 123182

Russian Federation

M. Ya. Smolyarchuk

Medicine and Nuclear Technologies LLC

ORCID iD: 0000-0001-9819-8657

Build. 322, 1 Akademika Kurchatova Ploshchad’, Moscow 123098

Russian Federation

T. N. Tolstykh

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0001-7308-0927

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

T. S. Chudnova

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-8012-1640

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

D. D. Ivanova

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0009-0004-3632-9198

3 Pekhotnaya St., Moscow 123182

Russian Federation

O. L. Kochneva

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0000-0003-1338-8203

3 Pekhotnaya St., Moscow 123182

Russian Federation

D. V. Lebedev

City Clinical Hospital No. 52, Moscow Healthcare Department; Medical and Biological University of Innovation and Continuing Education, State Scientific Center of the Russian Federation – A.I. Burnazyan Federal Medical Biophysical Center, Federal Medical and Biological Agency

ORCID iD: 0009-0001-8480-5505

3 Pekhotnaya St., Moscow 123182; 46 Zhivopisnaya St., Moscow 123098

Russian Federation

A. U. Abueva

City Clinical Hospital No. 52, Moscow Healthcare Department; Peoples’ Friendship University of Russia named after Patrice Lumumba

ORCID iD: 0009-0004-6952-4475

3 Pekhotnaya St., Moscow 123182; 6 Miklukho-Maklaya St., Moscow 117198

Russian Federation

A. M. Chistov

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

ORCID iD: 0009-0000-1477-9981

1 Ostrovityanova St., Moscow 117997

Russian Federation

E. N. Zotina

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0001-9692-2541

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

I. V. Samsonova

City Clinical Hospital No. 52, Moscow Healthcare Department; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

ORCID iD: 0000-0002-1228-1765

3 Pekhotnaya St., Moscow 123182; 1 Ostrovityanova St., Moscow 117997

Russian Federation

M. A. Lysenko

City Clinical Hospital No. 52, Moscow Healthcare Department; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

ORCID iD: 0000-0001-6010-7975

3 Pekhotnaya St., Moscow 123182; 1 Ostrovityanova St., Moscow 117997

Russian Federation

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