Опыт лечения рецидивов лимфомы Беркитта с применением таргетных препаратов и аутологичной/аллогенной трансплантации гемопоэтических стволовых клеток

Применение высокоэффективных многокомпонентных риск-адаптированных схем химиоиммунотерапии у детей с лимфомой Беркитта позволило добиться многолетней выживаемости без прогрессирования, превышающей 90 % даже у пациентов группы высокого риска. Единая тактика терапии рецидивирующих/рефрактерных форм заболевания не принята, а результаты использования карбоплатин- и гемцитабинсодержащих схем остаются неудовлетворительными. В статье приводится описание опыта использования ритуксимаба, ибрутиниба, ниволумаба в сочетании с полихимиотерапией и клинического наблюдения успешного лечения рецидивирующего течения лимфомы Беркитта с применением таргетных агентов, аутологичной и аллогенной трансплантации гемопоэтических стволовых клеток. Предложенная тактика терапии позволила получить полную ремиссию лимфомы Беркитта, но развившийся в короткие сроки после аллогенной трансплантации гемопоэтических стволовых клеток Т-линейный острый лимфобластный лейкоз стал фатальным для больного.

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