Cancer epidemiology in infants in Moscow region (population-based study)

   The aim of the study was to assess the main epidemiologic characteristics of cancer in infants in Moscow Region (MR).

   The database of childhood population-based cancer registry of MR served as a data source. 113 cancer cases were revealed during 1990–2008 years that comprised 6 % of all cases of cancer in children 0–14 years old. The male-to-female ratio was 1.2: 1. The incidence rate (IR) of cancer in infants was 9.0 per 100.000 in the retrospective part (1990–2000 years) and 15.4 per 100.000 in prospective part of the study (2001–2008 years). The unique distribution of cancer types in infants compared with children 1–14 years old was shown. The main diagnostic groups of cancer in infants were leukemia — 20 (17.7 %) cases, renal tumors — 19 (16.8 %) cases, neuroblastoma — 17 (15.0 %) cases. The IR of leading cancer types during 1990–2000 years was 1.9 for renal tumors, 1.7 for retinoblastoma and leukemia, during 2001–2008 years IR was 2.7 for leukemia, 2.4 for neuroblastoma, 2.1 for renal tumors. The overall survival (OS) of patients with all types of tumors diagnosed during 2001–2008 was 0.65 ± 0.07 with a median follow-up 29.5 months. The OS of patients with neuroblastoma was 0.91 ± 0,09, renal tumors — 0.67 ± 0,16, CNS tumors — 0.57 ± 0,19, leukemia — 0.33 ± 0,17.

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