Новые перспективы в лечении пациентов с миелодиспластическим синдромом промежуточного-2 и высокого риска
https://doi.org/10.17650/1818-8346-2022-17-4-106-117
Аннотация
В настоящее время терапевтическая тактика у пациентов с миелодиспластическим синдромом основана на проведении риск-адаптированной терапии с последующей аллогенной трансплантацией гемопоэтических стволовых клеток, которая остается единственным радикальным методом лечения. Для пациентов, которым невозможно проведение трансплантации, остается актуальной проблема поиска новых методов лечения. Современные знания о патогенезе заболевания позволяют получить представления о ключевых путях, связанных с онкогенезом, и разработать новые эпигенетические методы лечения.
В обзоре рассмотрены терапевтические подходы, применяемые в настоящее время при лечении пациентов с миелодиспластическим синдромом групп низкого и высокого риска, а также продемонстрирована актуальность поиска новых методов таргетной и иммунотерапии. Освещены достижения в области таргетной терапии, в частности изучение биологии молекулы TIM3 и ее лигандов, новые данные клинических испытаний моноклональных антител против TIM3.
Об авторах
Е. В. Морозова
НИИ детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России
Россия
Россия
197022 Санкт-Петербург, ул. Льва Толстого, 6–8
Н. Ю. Цветков
НИИ детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России
Россия
Россия
197022 Санкт-Петербург, ул. Льва Толстого, 6–8
М. В. Барабанщикова
НИИ детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России
Россия
Россия
197022 Санкт-Петербург, ул. Льва Толстого, 6–8
К. С. Юровская
НИИ детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России
Россия
Россия
197022 Санкт-Петербург, ул. Льва Толстого, 6–8
И. С. Моисеев
НИИ детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России
Россия
Россия
197022 Санкт-Петербург, ул. Льва Толстого, 6–8
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Рецензия
Для цитирования:
Морозова Е.В., Цветков Н.Ю., Барабанщикова М.В., Юровская К.С., Моисеев И.С. Новые перспективы в лечении пациентов с миелодиспластическим синдромом промежуточного-2 и высокого риска. Онкогематология. 2022;17(4):106-117. https://doi.org/10.17650/1818-8346-2022-17-4-106-117
For citation:
Morozova E.V., Tsvetkov N.Yu., Barabanshchikova M.V., Yurovskaya K.S., Moiseev I.S. New perspectives in the treatment of patients with intermediate-2 and high-risk myelodysplastic syndrome. Oncohematology. 2022;17(4):106-117. (In Russ.) https://doi.org/10.17650/1818-8346-2022-17-4-106-117
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