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The repertoire of heavy chain immunoglobulin genes in B‑cell chronic lymphocytic leukemia in Russia and Belarus
- Authors: Biderman B.V.1, Nikitin E.A.1, Sergienko T.F.2, Bakun A.V.2, Taras L.B.2, Svirnovskiy A.I.2, Sudarikov A.B.1
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Affiliations:
- Russian Hematological Research Center, Ministry of Health of Russia
- Scientific and Practical Center of Transfusiology and Medical Biotechnologies, Ministry of Health of the Republic of Belarus
- Issue: Vol 7, No 3 (2012)
- Pages: 38-42
- Section: BASIC RESEARCH
- Published: 22.08.2012
- URL: https://oncohematology.abvpress.ru/ongm/article/view/52
- DOI: https://doi.org/10.17650/1818-8346-2012-7-3-38-42
- ID: 52
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Abstract
Mutation status of the heavy chain variable region genes has long been known as an important factor in long‑term prognosis in B‑cell chronic lymphocytic leukemia (B‑CLL). A more detailed study of the gene sequences of immunoglobulin heavy chain (IgVH) led to the discovery of stereotyped antigen receptors (SAR) — receptors that have the same set of VH‑, D‑ and JH‑genes used. Cells with SARs have been found almost in a quarter of all B‑CLL cases. This phenomenon is not observed in other lymphatic tumors. In our study, we confirmed and extended the basic observations concerning the repertoire of IgVH in B‑CLL. Differences in the B‑CLL IgVH gene repertoirs between Russia, Вelarus and other countries are also analysed and discussed.
About the authors
B. V. Biderman
Russian Hematological Research Center, Ministry of Health of Russia
Author for correspondence.
Email: bella_biderman@mail.ru
Russian Federation
E. A. Nikitin
Russian Hematological Research Center, Ministry of Health of RussiaRussian Federation
T. F. Sergienko
Scientific and Practical Center of Transfusiology and Medical Biotechnologies, Ministry of Health of the Republic of BelarusRussian Federation
A. V. Bakun
Scientific and Practical Center of Transfusiology and Medical Biotechnologies, Ministry of Health of the Republic of BelarusRussian Federation
L. B. Taras
Scientific and Practical Center of Transfusiology and Medical Biotechnologies, Ministry of Health of the Republic of BelarusRussian Federation
A. I. Svirnovskiy
Scientific and Practical Center of Transfusiology and Medical Biotechnologies, Ministry of Health of the Republic of BelarusRussian Federation
A. B. Sudarikov
Russian Hematological Research Center, Ministry of Health of RussiaRussian Federation
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