The study of oncolytic viruses reproduction in organ cultures of human lymphoid tumors

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Abstract

Oncolytic viruses are promising agents for the treatment of various types of tumors, including malignant non-Hodgkin lymphomas. In order to identify the most effective candidates from a wide panel of non-pathogenic antitumor strains, a study was carried out of their ability to reproduce in short-term cultures of lymphoid tumor cells. Also, tumor cell cultures were characterized in relation to the presence of specific viral receptors CD54, CD55, CD155 on their surface.

About the authors

F. E. Babaeva

National Research Center for Hematology, Ministry of Health of Russia

Author for correspondence.
Email: fatima-babayeva1990@yandex.ru
ORCID iD: 0000-0002-5404-9024

4 Novyy Zykovskiy Proezd, Moscow 125167

Russian Federation

A. V. Lipatova

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

ORCID iD: 0000-0003-4501-8514

32 Vavilova St., Moscow 119991

Russian Federation

D. V. Kochetkov

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

32 Vavilova St., Moscow 119991

Russian Federation

P. M. Chumakov

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

ORCID iD: 0000-0002-8078-2908

32 Vavilova St., Moscow 119991

Russian Federation

S. K. Kravchenko

National Research Center for Hematology, Ministry of Health of Russia

ORCID iD: 0000-0002-7721-2074

4 Novyy Zykovskiy Proezd, Moscow 125167

Russian Federation

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