Generalized granulomatous inflammation caused by Candida lusitaniae in a patient with myelofibrosis
https://doi.org/10.17650/1818-8346-2019-14-4-67-72
Abstract
This article describes a clinical case demonstrating the difficulties of lifetime and post-mortem diagnosis in a patient with primary myelofibrosis complicated by a generalized fungal infection caused by a rare pathogen such as Candida lusitaniae. Management of such patients in non-specialized department with absence of bone marrow trepanobiopsy results associated with the variety of clinical situations in which such manifestations as neutrophilic leukocytosis with left shift without significant changes in the number of erythrocytes and platelets simultaneously with lymphadenopathy and visualizations of secondary foci in internal organs leads to wrong treatment management. And superposition of several pathological processes (granulomatous inflammation, foci of extramedulary hemopoesis and extensive necrotic changes) causes difficulties even for post-mortem verification of the diagnosis, that demonstrate the interest of this clinical case.
About the Authors
Yu. S. Korneva
Smolensk State Medical University, Ministry of Health of Russia; Smolensk Regional Institute of Pathology
Russian Federation
Russian Federation
28 Krupskoy St., Smolensk 214019; 27 Prospekt Gagarina, Smolensk 214018
O. V. Azovskova
Smolensk State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
28 Krupskoy St., Smolensk 214019
O. A. Shisterova
Smolensk Regional Oncology Clinical Dispensary
Russian Federation
Russian Federation
19 Zhukova St., Smolensk 214000
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Review
For citations:
Korneva Yu.S., Azovskova O.V., Shisterova O.A. Generalized granulomatous inflammation caused by Candida lusitaniae in a patient with myelofibrosis. Oncohematology. 2019;14(4):67-72. (In Russ.) https://doi.org/10.17650/1818-8346-2019-14-4-67-72
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