Адипоциты костного мозга при множественной миеломе
Аннотация
Множественная миелома, в основе возникновения которой лежит клональная пролиферация плазматических клеток в костном мозге, занимает одно из ведущих мест в структуре онкогематологических заболеваний. Патогенетические механизмы множественной миеломы пока окончательно не выяснены. Принято считать, что необходимое условие развития и прогрессирования заболевания – взаимодействие неопластических плазматических клеток с элементами костномозгового микроокружения, доминирующим клеточным компонентом которого являются адипоциты. В обзоре приведены новые данные, касающиеся характера и особенностей взаимодействия адипоцитов костного мозга с миеломными клетками, гемопоэтическими стволовыми клетками и клетками-предшественниками, мезенхимальными стволовыми клетками, остеобластами, остеокластами, эндотелиальными клетками и клетками иммунной системы. Особое внимание уделено вырабатываемым адипоцитами костного мозга адипокинам, факторам роста, цитокинам, хемокинам и свободным жирным кислотам, которые в той или иной мере обеспечивают условия для предпочтительного роста и миграции опухолевых плазматических клеток, угнетения гемопоэза, резорбции костной ткани, активации ангиогенеза и формирования иммуносупрессии.
Об авторе
A. A. Фильченков
Институт экспериментальной патологии, онкологии и радиобиологии им. Р.Е. Кавецкого НАН Украины; 03022 Киев, ул. Васильковская, 45
Украина
Украина
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Для цитирования:
Фильченков A.A. Адипоциты костного мозга при множественной миеломе. Онкогематология. 2019;14(1):60-75. https://doi.org/10.17650/1818-8346-2019-14-1-60-75
For citation:
Philchenkov A.A. Bone marrow adipocytes and multiple myeloma. Oncohematology. 2019;14(1):60-75. (In Russ.) https://doi.org/10.17650/1818-8346-2019-14-1-60-75
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