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Эффективность и безопасность ингибиторов тирозинкиназ 2-го поколения (дазатиниб, нилотиниб) в терапии хронической фазы хронического миелолейкоза

https://doi.org/10.17650/1818-8346-2013-8-2-22-33

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Аннотация

Современные возможности терапии хронического миелолейкоза (ХМЛ) иматинибом (ИМ) позволили достигнуть длительной беспрогрессивной и общей выживаемости, а также высокого качества жизни пациентов. В случаях развития резистентности к ИМ или его непереносимости в настоящее время возможно также проведение терапии ингибиторами тирозинкиназ 2-го поколения – дазатинибом и нилотинибом. В статье представлен обзор литературы с оценкой эффективности и возможного профиля токсичности обоих препаратов, с освещением наиболее актуальных практических вопросов лечения ХМЛ при неудаче терапии первой линии.

Об авторах

Е. Г. Ломаиа
ФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздрава России
Россия


Е. Г. Романова
ФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздрава России
Россия


Е. И. Сбитякова
ФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздрава России ФГБУ «Санкт-Петербургский государственный медицинский университет им. И.П. Павлова» Минздрава России
Россия


А. Ю. Зарицкий
ФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздрава России ФГБУ «Санкт-Петербургский государственный медицинский университет им. И.П. Павлова» Минздрава России
Россия


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Для цитирования:


Ломаиа Е.Г., Романова Е.Г., Сбитякова Е.И., Зарицкий А.Ю. Эффективность и безопасность ингибиторов тирозинкиназ 2-го поколения (дазатиниб, нилотиниб) в терапии хронической фазы хронического миелолейкоза. Онкогематология. 2013;8(2):22-33. https://doi.org/10.17650/1818-8346-2013-8-2-22-33

For citation:


Lomaia E.G., Romanova E.G., Sbityakova E.I., Zaritskiy A.Y. Efficacy and safety of tyrosine kinase inhibitors (dasatinib, nilotinib) in the treatment of chronic phase chronic myeloid leukemia. Oncohematology. 2013;8(2):22-33. (In Russ.) https://doi.org/10.17650/1818-8346-2013-8-2-22-33

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ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)