РОЛЬ И МЕСТО ПРОТОЧНОЙ ЦИТОМЕТРИИ В ДИАГНОСТИКЕ И МОНИТОРИНГЕ МИНИМАЛЬНОЙ ОСТАТОЧНОЙ БОЛЕЗНИ ПРИ МНОЖЕСТВЕННОЙ МИЕЛОМЕ
https://doi.org/10.17650/1818-8346-2017-12-2-80-94
Аннотация
За последние 20 лет подходы к терапии множественной миеломы претерпели значительные изменения, и частота достижения ремиссии заболевания увеличилась. Использование новых диагностических методов позволило более достоверно оценивать ответ на терапию и прогнозировать возникновение рецидива: аллель-специфичная полимеразная цепная реакция, секвенирование нового поколения, многоцветная проточная цитометрия позволяют обнаруживать минимальную остаточную болезнь (МОБ) с чувствительностью от 10–5 до 10–6. Оценка МОБ с помощью проточной цитометрии – динамично развивающееся направление исследований. Задачами многоцентровых исследований, использующих проточную цитометрию в качестве инструмента для поиска МОБ при множественной миеломе, являются стандартизация, увеличение чувствительности и специфичности данного метода. Цель публикации – представление данных о методах, применяющихся для мониторинга МОБ и достижений в области проточной цитометрии.
Об авторах
И. В. Гальцева
ФГБУ «Гематологический научный центр» Минздрава России
Россия
Россия
Контакты: Гальцева Ирина Владимировна
125167 Москва, Новый Зыковский проезд, 4а
Ю. О. Давыдова
ФГБУ «Гематологический научный центр» Минздрава России
Россия
Россия
125167 Москва, Новый Зыковский проезд, 4а
Н. М. Капранов
ФГБУ «Гематологический научный центр» Минздрава России
Россия
Россия
125167 Москва, Новый Зыковский проезд, 4а
У. Л. Джулакян
ФГБУ «Гематологический научный центр» Минздрава России
Россия
Россия
125167 Москва, Новый Зыковский проезд, 4а
Л. П. Менделеева
ФГБУ «Гематологический научный центр» Минздрава России
Россия
Россия
125167 Москва, Новый Зыковский проезд, 4а
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Рецензия
Для цитирования:
Гальцева И.В., Давыдова Ю.О., Капранов Н.М., Джулакян У.Л., Менделеева Л.П. РОЛЬ И МЕСТО ПРОТОЧНОЙ ЦИТОМЕТРИИ В ДИАГНОСТИКЕ И МОНИТОРИНГЕ МИНИМАЛЬНОЙ ОСТАТОЧНОЙ БОЛЕЗНИ ПРИ МНОЖЕСТВЕННОЙ МИЕЛОМЕ. Онкогематология. 2017;12(2):80-94. https://doi.org/10.17650/1818-8346-2017-12-2-80-94
For citation:
Galtseva I.V., Davydova Y.O., Kapranov N.M., Julakyan U.L., Mendeleeva L.P. FLOW CYTOMETRY IN THE DIAGNOSIS AND MONITORING OF MINIMAL RESIDUAL DISEASE IN MULTIPLE MYELOMA. Oncohematology. 2017;12(2):80-94. (In Russ.) https://doi.org/10.17650/1818-8346-2017-12-2-80-94
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