Physiology and pathology of extracellular vesicules
https://doi.org/10.17650/1818-8346-2017-12-1-62-70
Abstract
This year marks the 50th anniversary of the first publication about blood plasma microparticles. Initially considered as cell fragments or “platelet dust”, extracellular vesicles currently attracted the attention of biochemists, biophysicists, physicians, pharmacists around the world. They are heterogeneous in structure and derived from many cell types, express different antigen and contain variety of biomolecules that determines wide range of biological activity, including procoagulant, regenerative, immunomodulating, and others. They play an important role in the pathophysiology of different diseases and conditions – from infarction, injuries and pregnancies to the “graft versus host” disease. The vesicles as medicaments and their carriers, as well as the drugs that affect them, are a rapidly developing field of research.
About the Authors
M. A. Panteleev
National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS;
Lomonosov Moscow State University;
Moscow Institute of Physics and Technology (State University);
Russian Federation
Russian Federation
1 Samory Mashela St., Moscow, Russia, 117997;
38A-1 Leninsky Avenue, Moscow 119991, Russia;
Faculty of Physics
1-2 Leniskie Gory, Moscow 119991, Russia;
Department of Biological and Medical Physics
9 Institutskiy Lane, Dolgoprudny, Moscow Region 141700, Russia
A. A. Abaeva
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS;
Russian Federation
Russian Federation
38A-1 Leninsky Avenue, Moscow 119991, Russia;
D. Yu. Nechipurenko
National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS;
Lomonosov Moscow State University;
Russian Federation
Russian Federation
1 Samory Mashela St., Moscow, Russia, 117997;
38A-1 Leninsky Avenue, Moscow 119991, Russia;
Faculty of Physics
1-2 Leniskie Gory, Moscow 119991, Russia;
S. I. Obydenniy
National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS;
Russian Federation
Russian Federation
1 Samory Mashela St., Moscow, Russia, 117997;
38A-1 Leninsky Avenue, Moscow 119991, Russia;
A. N. Sveshnikova
National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS;
Lomonosov Moscow State University;
Russian Federation
Russian Federation
1 Samory Mashela St., Moscow, Russia, 117997;
38A-1 Leninsky Avenue, Moscow 119991, Russia;
Faculty of Physics
1-2 Leniskie Gory, Moscow 119991, Russia;
A. M. Shibeko
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS;
Russian Federation
38A-1 Leninsky Avenue, Moscow 119991, Russia;
Russian Federation
38A-1 Leninsky Avenue, Moscow 119991, Russia;
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Review
For citations:
Panteleev M.A., Abaeva A.A., Nechipurenko D.Yu., Obydenniy S.I., Sveshnikova A.N., Shibeko A.M. Physiology and pathology of extracellular vesicules. Oncohematology. 2017;12(1):62-70. (In Russ.) https://doi.org/10.17650/1818-8346-2017-12-1-62-70
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