How to use ibrutinib
https://doi.org/10.17650/1818-8346-2017-12-1-33-43
Abstract
The emergence of new targeted drugs, affecting B-cell receptor signaling pathway opens a new page in the treatment of chronic lymphocytic leukemia (CLL). It is not simply expanding choice, it will likely to change total strategy of CLL management. Clinical trials have shown improvement of overall survival in CLL patients in both first line and relapsed disease settings. Targeted drugs lack typical complications of chemotherapy, such as myelosupression. However, they have their specific side effects that require particular attention to avoid unjustified dose reduction and treatment cessation. The present review focuses on practical use of ibrutinib, the first inhibitor of Bruton’s tyrosinkinase.
About the Authors
Е. А. Nikitin
S.P. Botkin City Clinical Hospital, Moscow Heаlthcare Department;
Russian Federation
5, 2nd Botkinskiy Proezd, Moscow 125284, Russia;
Russian Federation
5, 2nd Botkinskiy Proezd, Moscow 125284, Russia;
V. I. Vorobiev
S.P. Botkin City Clinical Hospital, Moscow Heаlthcare Department;
Russian Federation
5, 2nd Botkinskiy Proezd, Moscow 125284, Russia;
Russian Federation
5, 2nd Botkinskiy Proezd, Moscow 125284, Russia;
М. А. Panteleev
National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;
Russian Federation
1 Samory Mashela St., Moscow 117997, Russia;
Russian Federation
1 Samory Mashela St., Moscow 117997, Russia;
G. E. Gendlin
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia;
Russian Federation
1 Ostrovityanova St., Moscow 117997, Russia
Russian Federation
1 Ostrovityanova St., Moscow 117997, Russia
V. V. Ptushkin
S.P. Botkin City Clinical Hospital, Moscow Heаlthcare Department;
Russian Federation
5, 2nd Botkinskiy Proezd, Moscow 125284, Russia;
Russian Federation
5, 2nd Botkinskiy Proezd, Moscow 125284, Russia;
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Review
For citations:
Nikitin Е.А., Vorobiev V.I., Panteleev М.А., Gendlin G.E., Ptushkin V.V. How to use ibrutinib. Oncohematology. 2017;12(1):33-43. (In Russ.) https://doi.org/10.17650/1818-8346-2017-12-1-33-43
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