Как применять ибрутиниб
https://doi.org/10.17650/1818-8346-2017-12-1-33-43
Аннотация
Появление таргетных препаратов открывает новую страницу в лечении больных хроническим лимфолейкозом (ХЛЛ). Это означает не только расширение терапевтического выбора, но и, возможно, изменение всей тактики ведения ХЛЛ в ближайшем будущем. В клинических исследованиях ибрутиниба впервые показано увеличение продолжительности жизни у больных с рефрактерным ХЛЛ по сравнению с данными исторического контроля, а затем и в рандомизированном сравнении с офатумумабом.
Таргетным препаратам не свойственны типичные осложнения химиотерапии, такие как миелосупрессия. Тем не менее таргетные препараты имеют свои осложнения. Неумелое использование может привести к преждевременному прекращению приема или редукции доз, что скажется на успехе лечения.
Данный обзор посвящен практике применения ибрутиниба – первого в своем классе ингибитора сигнального пути В-клеточного рецептора
Об авторах
Е. А. НикитинРоссия
Россия, 125284 Москва, 2-й Боткинский проезд, 5;
В. И. Воробьев
Россия
Россия, 125284 Москва, 2-й Боткинский проезд, 5;
М. А. Пантелеев
Россия
Лаборатория клеточного гемостаза и тромбоза
Россия, 117997 Москва, ул. Саморы Машела, 1;
Г. Е. Гендлин
Россия
Кафедра госпитальной терапии № 2
Россия, 117997 Москва, ул. Островитянова, 1
В. В. Птушкин
Россия
Россия, 125284 Москва, 2-й Боткинский проезд, 5;
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Рецензия
Для цитирования:
Никитин Е.А., Воробьев В.И., Пантелеев М.А., Гендлин Г.Е., Птушкин В.В. Как применять ибрутиниб. Онкогематология. 2017;12(1):33-43. https://doi.org/10.17650/1818-8346-2017-12-1-33-43
For citation:
Nikitin Е.А., Vorobiev V.I., Panteleev М.А., Gendlin G.E., Ptushkin V.V. How to use ibrutinib. Oncohematology. 2017;12(1):33-43. (In Russ.) https://doi.org/10.17650/1818-8346-2017-12-1-33-43