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Как применять ибрутиниб

https://doi.org/10.17650/1818-8346-2017-12-1-33-43

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Аннотация

Появление таргетных препаратов открывает новую страницу в лечении больных хроническим лимфолейкозом (ХЛЛ). Это означает не только расширение терапевтического выбора, но и, возможно, изменение всей тактики ведения ХЛЛ в ближайшем будущем. В клинических исследованиях ибрутиниба впервые показано увеличение продолжительности жизни у больных с рефрактерным ХЛЛ по сравнению с данными исторического контроля, а затем и в рандомизированном сравнении с офатумумабом.
Таргетным препаратам не свойственны типичные осложнения химиотерапии, такие как миелосупрессия. Тем не менее таргетные препараты имеют свои осложнения. Неумелое использование может привести к преждевременному прекращению приема или редукции доз, что скажется на успехе лечения.
Данный обзор посвящен практике применения ибрутиниба – первого в своем классе ингибитора сигнального пути В-клеточного рецептора

Об авторах

Е. А. Никитин
ГБУЗ г. Москвы «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»;
Россия
Россия, 125284 Москва, 2-й Боткинский проезд, 5;


В. И. Воробьев
ГБУЗ г. Москвы «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»;
Россия
Россия, 125284 Москва, 2-й Боткинский проезд, 5;


М. А. Пантелеев
ФГБУ «Национальный научно-практический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России;
Россия

Лаборатория клеточного гемостаза и тромбоза

Россия, 117997 Москва, ул. Саморы Машела, 1;



Г. Е. Гендлин
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России;
Россия

Кафедра госпитальной терапии № 2

Россия, 117997 Москва, ул. Островитянова, 1



В. В. Птушкин
ГБУЗ г. Москвы «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»;
Россия
Россия, 125284 Москва, 2-й Боткинский проезд, 5;


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Для цитирования:


Никитин Е.А., Воробьев В.И., Пантелеев М.А., Гендлин Г.Е., Птушкин В.В. Как применять ибрутиниб. Онкогематология. 2017;12(1):33-43. https://doi.org/10.17650/1818-8346-2017-12-1-33-43

For citation:


Nikitin Е.А., Vorobiev V.I., Panteleev М.А., Gendlin G.E., Ptushkin V.V. How to use ibrutinib. Oncohematology. 2017;12(1):33-43. (In Russ.) https://doi.org/10.17650/1818-8346-2017-12-1-33-43

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ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)