Адоптивная иммунотерапия генетически модифицированными Т-лимфоцитами, экспрессирующими химерные антигенные рецепторы
Аннотация
Значительная смертность от онкологических заболеваний в целом и онкогематологических в частности побуждает научно-медицинское сообщество к разработке новых методов лечения. Одним из новейших методов является адоптивная клеточная терапия с использованием генетически-модифицированных Т-лимфоцитов больного, экспрессирующих химерные антигенные рецепторы (CAR) к специфическим опухолевым антигенам. Несмотря на высокую стоимость и наличие осложнений в применении, многообещающие клинические испытания у больных даже на поздних стадиях онкозаболеваний позволяют раcсчитывать на успешное внедрение этого метода в практику.
В статье представлен обзор основных принципов данной технологии, опубликованных результатов клинических испытаний СAR T-клеток с акцентом на таргетирование антигена CD19, осложнений данной терапии, механизмов резистентности опухолей к действию CAR T-клеток и потенциальных путей ее преодоления.
Об авторах
А. А. Павлова
Сколковский институт науки и технологий, инновационный центр «Сколково»;
Мемориальный онкологический центр Слоун Кеттеринг;
Россия
Россия, 143026 Москва, ул. Нобеля, 3;
США, 10065 Нью-Йорк, Йорк-авеню 1275;
Россия
Россия, 143026 Москва, ул. Нобеля, 3;
США, 10065 Нью-Йорк, Йорк-авеню 1275;
М. А. Масчан
ФГБУ «Национальный научно-практический центр детской гематологии,
онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России;
Россия
Лаборатория клеточного гемостаза и тромбоза
Россия, 117997 Москва, ул. Саморы Машела, 1
Россия
Лаборатория клеточного гемостаза и тромбоза
Россия, 117997 Москва, ул. Саморы Машела, 1
В. Б. Пономарев
Мемориальный онкологический центр Слоун Кеттеринг;
Соединённые Штаты Америки
10065 Нью-Йорк, Йорк-авеню 1275;
Соединённые Штаты Америки
10065 Нью-Йорк, Йорк-авеню 1275;
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Для цитирования:
Павлова А.А., Масчан М.А., Пономарев В.Б. Адоптивная иммунотерапия генетически модифицированными Т-лимфоцитами, экспрессирующими химерные антигенные рецепторы. Онкогематология. 2017;12(1):17-32. https://doi.org/10.17650/1818-8346-2017-12-1-17-32
For citation:
Pavlova A.А., Maschan M.А., Ponomarev V.B. Adoptitive immunotherapy with genetically engineered T lymphocytes modified to express chimeric antigen receptors. Oncohematology. 2017;12(1):17-32. (In Russ.) https://doi.org/10.17650/1818-8346-2017-12-1-17-32
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