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МОЛЕКУЛЯРНО-БИОЛОГИЧЕСКИЕ ХАРАКТЕРИСТИКИ ALK-ПОЗИТИВНОЙ АНАПЛАСТИЧЕСКОЙ КРУПНОКЛЕТОЧНОЙ ЛИМФОМЫ

https://doi.org/10.17650/1818-8346-2016-11-4-25-31

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Аннотация

ALK-позитивная анапластическая крупноклеточная лимфома представляет гетерогенную группу зрелых Т-клеточных неходжкинских лимфом, которая характеризуется экспрессией СD30/Ki-1 и типичной транслокацией с вовлечением гена тирозинкиназы анапластической лимфомы. В последнее время большое внимание уделяют выявлению прогностических факторов течения данного заболевания. К ним относят клинические, гистологические и молекулярно-генетические особенности, связанные с активацией внутриклеточных сигнальных путей. В данном обзоре рассматриваются механизмы действия киназы анапластической лимфомы и возможные молекулярные мишени таргетной терапии.

Об авторах

Е. В. Чернышова
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева
Россия
117997 Москва, ул. Саморы Машела, 1


Д. С. Абрамов
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева
Россия

Дмитрий Сергеевич Абрамов.

117997 Москва, ул. Саморы Машела, 1,  abramovd_s@bk.ru



Д. М. Коновалов
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева
Россия
117997 Москва, ул. Саморы Машела, 1


С. С. Ларин
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева
Россия
117997 Москва, ул. Саморы Машела, 1


Н. В. Мякова
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева
Россия
117997 Москва, ул. Саморы Машела, 1


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Для цитирования:


Чернышова Е.В., Абрамов Д.С., Коновалов Д.М., Ларин С.С., Мякова Н.В. МОЛЕКУЛЯРНО-БИОЛОГИЧЕСКИЕ ХАРАКТЕРИСТИКИ ALK-ПОЗИТИВНОЙ АНАПЛАСТИЧЕСКОЙ КРУПНОКЛЕТОЧНОЙ ЛИМФОМЫ. Онкогематология. 2016;11(4):25-31. https://doi.org/10.17650/1818-8346-2016-11-4-25-31

For citation:


Chernyshova E.V., Abramov D.S., Konovalov D.M., Larin S.S., Myakova N.V. MOLECULAR BIOLOGICAL CHARACTERISTICS OF ALK-POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA. Oncohematology. 2016;11(4):25-31. (In Russ.) https://doi.org/10.17650/1818-8346-2016-11-4-25-31

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ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)