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BRAF and MAP2K1 mutations in hairy cell leukemia and splenic marginal zone B-cell lymphoma
- Authors: Yakutik I.A.1,2, Al’-Radi L.S.1,2, Julhakyan H.L.1,2, Biderman B.V.1,2, Sudarikov A.B.1,2
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Affiliations:
- National Research Center for Hematology, Ministry of Health of Russia
- 4 Novyy Zykovskiy Proezd, Moscow, 125167, Russia
- Issue: Vol 11, No 1 (2016)
- Pages: 34-36
- Section: HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE
- Published: 31.03.2016
- URL: https://oncohematology.abvpress.ru/ongm/article/view/179
- DOI: https://doi.org/10.17650/1818-8346-2016-11-1-34-36
- ID: 179
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Abstract
DNA samples from patients with hairy cell leukemia (HCL) and splenic marginal zone B-cell lymphoma (MZBCL) for BRAF and MAP2K1 activating mutations were analyzed. V600E mutation of BRAF was detected in 39 (98 %) of 40 patients with hairy cell leukemia, and no patient with MZBCL. In none of the patients in this study any other activating mutations than V600E in exons 11 and 15 of BRAF gene were revealed. MAP2K1 Q56P mutation characterized by IGHV4-34 expression was detected in 1 (2 %) of 40 patients with HCL. In none of the patients with MZBCL activating mutations in the 2, 3 or 11 exons of MAR2K1 gene have been identified, including those with IGHV4-34 expression.
About the authors
I. A. Yakutik
National Research Center for Hematology, Ministry of Health of Russia; 4 Novyy Zykovskiy Proezd, Moscow, 125167, Russia
Author for correspondence.
Email: igorya90@list.ru
Russian Federation
L. S. Al’-Radi
National Research Center for Hematology, Ministry of Health of Russia; 4 Novyy Zykovskiy Proezd, Moscow, 125167, RussiaRussian Federation
H. L. Julhakyan
National Research Center for Hematology, Ministry of Health of Russia; 4 Novyy Zykovskiy Proezd, Moscow, 125167, RussiaRussian Federation
B. V. Biderman
National Research Center for Hematology, Ministry of Health of Russia; 4 Novyy Zykovskiy Proezd, Moscow, 125167, RussiaRussian Federation
A. B. Sudarikov
National Research Center for Hematology, Ministry of Health of Russia; 4 Novyy Zykovskiy Proezd, Moscow, 125167, RussiaRussian Federation
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