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Генетическая гетерогенность острых лейкозов у детей первого года жизни

https://doi.org/10.17650/1818-8346-2016-11-1-14-23

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Аннотация

В работе представлены литературные данные и собственные наблюдения за пациентами первого года жизни с острыми лейкозами. Комплексная характеристика острых лейкозов в этой возрастной группе с использованием данных цитогенетики, флуоресцентной гибридизации in situ, различных вариантов полимеразной цепной реакции как при наличии перестроек 11q23/MLL, так и при их отсутствии встречается крайне редко. Проанализированы как частые, так и редкие цитогенетические и молекулярно-генетические характеристики пациентов с острыми лимфобластными и острыми миелоидными лейкозами в данной возрастной группе.

Об авторах

Г. А. Цаур
ГБУЗ СО «Областная детская клиническая больница № 1»; Россия, 620149, Екатеринбург, ул. С. Дерябиной, 32 ГАУЗ СО «Институт медицинских клеточных технологий»; Россия, 620026, Екатеринбург, ул. Карла Маркса, 22а ФГАОУ ВПО «Уральский федеральный университет им. первого Президента России Б. Н. Ельцина»; Россия, 620002, Екатеринбург, ул. Мира, 19
Россия


Е. В. Флейшман
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России; Россия, 115478, Москва, Каширское шоссе, 23
Россия


А. М. Попов
ФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России; Россия, 117998, Москва, ул. Саморы Машела, 1
Россия


Л. Г. Фечина
ГБУЗ СО «Областная детская клиническая больница № 1»; Россия, 620149, Екатеринбург, ул. С. Дерябиной, 32
Россия


С. А. Румянцев
ФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России; Россия, 117998, Москва, ул. Саморы Машела, 1 ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России; Россия, 117997, Москва, ул. Островитянова, 1
Россия


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Для цитирования:


Цаур Г.А., Флейшман Е.В., Попов А.М., Фечина Л.Г., Румянцев С.А. Генетическая гетерогенность острых лейкозов у детей первого года жизни. Онкогематология. 2016;11(1):14-23. https://doi.org/10.17650/1818-8346-2016-11-1-14-23

For citation:


Tsaur G.A., Fleischman E.W., Popov A.M., Fechina L.G., Rumyantsev S.A. Genetic heterogeneity of infant acute leukemias. Oncohematology. 2016;11(1):14-23. (In Russ.) https://doi.org/10.17650/1818-8346-2016-11-1-14-23

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ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)