Ocular involvement in pediatric patients with acute leukemia relapse: points of diagnosis and treatment
https://doi.org/10.17650/1818-8346-2025-20-1-73-79
Abstract
In consequence of the development of modern chemotherapy protocols, the prognosis for children with acute leukemia(AL) has significantly improved, which has allowed achieving high survival rates. However, despite these achievements, relapses and refractory course of AL are not uncommon. Extramedullary relapses with the kidneys, gonads, soft tissues, central nervous system and eyes involvement are especially difficult to diagnose. Clinical manifestations of eye involvement in AL can be represented by decreased vision, swelling of the optic disc, exophthalmos, due to infiltration of the optic nerve and intraorbital tissues by leukemic blasts. The alertness of pediatric oncologists and ophthalmologists regarding the possibility of AL relapses with eye localization should determine the scope of examination, including MRI, retinal camera examination, spinal tap and morphological and immunological verification of the pathological process. unfortunately, intraocular AL relapses currently often have an extremely poor prognosis.
Supporting agencies: The work was performed without external funding
About the Authors
G. A. Radzhabova
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
Galimat Abdulkhalikovna Radzhabova
125993; Build. 1, 2 / 1 Barrikadnaya St.; Moscow
V. D. Mashchyts
Republican Scientific and Practical Center for Children’s Oncology, Hematology and Immunology
Belarus
Belarus
223053; 43 Frunzenskaya St.; Minsk Region; Borovlyany
L. V. Naumenko
N.N. Alexandrov Republican Research and Practical Center for Oncology and Medical Radiology
Belarus
Belarus
223040; Minsk Region; Lesnoy
T. T. Valiev
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation
Russian Federation
125993; Build. 1, 2 / 1 Barrikadnaya St.; 155522; 24 Kashirskoe Shosse; 119991; Build. 2, 8 Trubetskaya St.; Moscow
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For citations:
Radzhabova G.A., Mashchyts V.D., Naumenko L.V., Valiev T.T. Ocular involvement in pediatric patients with acute leukemia relapse: points of diagnosis and treatment. Oncohematology. 2025;20(1):73-79. (In Russ.) https://doi.org/10.17650/1818-8346-2025-20-1-73-79
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