Метаболический профиль бластных клеток при остром миелоидном лейкозе. Обзор литературы
https://doi.org/10.17650/1818-8346-2024-19-4-173-181
Аннотация
Представлен обзор новых данных о метаболизме и механизмах его регулирования в бластных клетках при остром миелоидном лейкозе. Основное внимание уделено роли активных форм кислорода в регуляции сигнальных путей и метаболических процессов, а также их влиянию на агрессивность острого миелоидного лейкоза и его резистентность к химиотерапевтическим препаратам. Повышенные уровни активных форм кислорода ассоциированы с измененной активностью ферментов и белков, участвующих в клеточной пролиферации и выживании. Также рассмотрены данные о роли железа в формировании злокачественности острого миелоидного лейкоза.
Об авторах
А. В. Халиулин
ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России
Россия
Россия
Алмаз Вадимович Халиулин,
443099 Самара, ул. Чапаевская, 89
И. И. Занин
ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России
Россия
Россия
443099 Самара, ул. Чапаевская, 89
А. В. Лямин
ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России
Россия
Россия
443099 Самара, ул. Чапаевская, 89
И. Л. Давыдкин
ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России
Россия
Россия
443099 Самара, ул. Чапаевская, 89
И. А. Селезнева
ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России
Россия
Россия
443099 Самара, ул. Чапаевская, 89
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Рецензия
Для цитирования:
Халиулин А.В., Занин И.И., Лямин А.В., Давыдкин И.Л., Селезнева И.А. Метаболический профиль бластных клеток при остром миелоидном лейкозе. Обзор литературы. Онкогематология. 2024;19(4):173-181. https://doi.org/10.17650/1818-8346-2024-19-4-173-181
For citation:
Khaliulin A.V., Zanin I.I., Lyamin A.V., Davydkin I.L., Selezneva I.A. Metabolic profile of blast cells in acute myeloid leukemia. Literature review. Oncohematology. 2024;19(4):173-181. (In Russ.) https://doi.org/10.17650/1818-8346-2024-19-4-173-181
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