Nivolumab-containing therapy in patients with newly diagnosed classical Hodgkin lymphoma: own clinical observations and literature review

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Abstract

Classical Hodgkin’s lymphoma (cHL) is a lymphoproliferative disease characterized by the presence of Hodgkin anderezovsky–Reed–Sternberg cells and a tumor microenvironment. Currently, much attention is paid to the microenvironment in cLH. A detailed understanding of the interaction between the tumor and its microenvironment opens up prospects for the cHL diagnosis and treatment. Innovative immunotherapeutic agents such as nivolumab make it possible to control and activate the immune response. Despite the high efficiency of standard protocols in young patients, therapy intensification is associated with organ toxicity and the development of secondary malignant neoplasms. At the same time, in elderly patients, the results of generally accepted antitumor treatment protocols should be considered suboptimal. In the last decade, the treatment of refractory cHL has improved significantly due to the use of immune checkpoint inhibitors.

Taking into account the above, the priority issue in modern clinical hematology is to improve cHL treatment strategies not only in elderly but also in young patients by maintaining a balance between high efficacy and low toxicity. Moreover, the inclusion of nivolumab in first-line therapy is not only pathogenetically justified and effective, but also safe. The article presents data from clinical observations of the successful nivolumab use in combination with chemotherapy in patients with newly diagnosed cHL.

About the authors

D. D. Ivanova

Moscow City Clinical Hospital No. 52;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Author for correspondence.
Email: doc.ivanovadd@gmail.com
ORCID iD: 0009-0004-3632-9198

Diana Davidovna Ivanova,

3 Pekhotnaya St., Moscow 123182;

Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. A. Baryakh

Moscow City Clinical Hospital No. 52;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University);
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

ORCID iD: 0000-0001-6880-9269

3 Pekhotnaya St., Moscow 123182;

Build. 2, 8 Trubetskaya St., Moscow 119991;

Build 1, 2/1 Barrikadnaya St., Moscow 125993

Russian Federation

M. A. Mingalimov

Moscow City Clinical Hospital No. 52;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-8491-2140

3 Pekhotnaya St., Moscow 123182;

Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. N. Misyurina

Moscow City Clinical Hospital No. 52;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0003-2419-4850

3 Pekhotnaya St., Moscow 123182;

Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

D. S. Polyakov

Moscow City Clinical Hospital No. 52

ORCID iD: 0009-0006-9607-6924

3 Pekhotnaya St., Moscow 123182

Russian Federation

N. A. Savosina

Moscow City Clinical Hospital No. 52

ORCID iD: 0009-0002-5477-4645

3 Pekhotnaya St., Moscow 123182

Russian Federation

M. M. Beregov

Federal Center of Brain Research and Neurotechnologies, Federal Medical and Biological Agency

ORCID iD: 0000-0003-1899-8131

Build. 10, 1 Ostrovityanova St., Moscow 117513

Russian Federation

M. A. Donskoy

Moscow International Oncology Center

ORCID iD: 0009-0007-1757-4683

Build. 4, 26 Durova St., Moscow 129090

Russian Federation

A. B. Makeshova

Moscow City Clinical Hospital No. 52;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-0414-2554

3 Pekhotnaya St., Moscow 123182;

Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

T. N. Tolstykh

Moscow City Clinical Hospital No. 52;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0001-7308-0927

3 Pekhotnaya St., Moscow 123182;

Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

O. L. Kochneva

Moscow City Clinical Hospital No. 52

ORCID iD: 0000-0003-1338-8203

3 Pekhotnaya St., Moscow 123182

Russian Federation

T. S. Kravchuk

Moscow City Clinical Hospital No. 52;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-8012-1640

3 Pekhotnaya St., Moscow 123182;

Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. I. Zhelnova

Moscow City Clinical Hospital No. 52;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-0343-9348

3 Pekhotnaya St., Moscow 123182;

Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

K. V. Yatskov

Moscow City Clinical Hospital No. 52

ORCID iD: 0000-0003-0125-9068

3 Pekhotnaya St., Moscow 123182

Russian Federation

A. Kh. Mnoyan

Moscow City Clinical Hospital No. 52

ORCID iD: 0000-0002-0527-4030

3 Pekhotnaya St., Moscow 123182

Russian Federation

I. M. Grashchenko

Moscow City Clinical Hospital No. 52

ORCID iD: 0009-0002-5595-148X

3 Pekhotnaya St., Moscow 123182

Russian Federation

N. A. Shevchenko

Moscow City Clinical Hospital No. 52

ORCID iD: 0000-0002-1216-5721

3 Pekhotnaya St., Moscow 123182

Russian Federation

A. A. Vinokurov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

ORCID iD: 0000-0003-0441-0034

1 Samory Mashela St., Moscow 117997

Russian Federation

I. V. Samsonova

Moscow City Clinical Hospital No. 52

ORCID iD: 0000-0002-1228-1765

3 Pekhotnaya St., Moscow 123182

Russian Federation

M. A. Lysenko

Moscow City Clinical Hospital No. 52

ORCID iD: 0000-0001-6010-7975

3 Pekhotnaya St., Moscow 123182

Russian Federation

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