Нарушения в системе белка р53 и их влияние на патогенез хронических лимфопролиферативных заболеваний
Аннотация
В настоящее время активно обсуждается роль белков семейства р53 как в рамках патогенеза хронических лимфопролиферативных заболеваний, так и в свете растущего интереса к терапевтическому потенциалу так называемых малых молекул, способных влиять на регуляторные «взаимоотношения» молекул р53, MDM2, p21 и PUM A. Представленная статья является попыткой обобщить данные экспериментальных моделей на тканях опухоли и мышиных моделях и доступных в литературе исследований с использованием материала лимфоидных опухолей человека. Рассмотрены как аспекты прогностической значимости экспрессии белков семейства р53 при лимфопролиферативных заболеваниях, так и возможные терапевтические подходы, использующие
особенности взаимоотношений р53-молекулы с генами-регуляторами и эффекторами.
Ключевые слова
хронические лимфопролиферативные заболевания,
лимфомы,
хронический лимфолейкоз,
апоптоз,
р53,
MDM2,
p21,
PUMA
Об авторах
П. М. Кондратовский
Владивостокский государственный медицинский университет
Россия
Россия
А. И. Дубиков
Владивостокский государственный медицинский университет
Россия
Россия
А. Ю. Дорошевская
Владивостокский государственный медицинский университет
Россия
Россия
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Для цитирования:
Кондратовский П.М., Дубиков А.И., Дорошевская А.Ю. Нарушения в системе белка р53 и их влияние на патогенез хронических лимфопролиферативных заболеваний. Онкогематология. 2011;6(3):65-75. https://doi.org/10.17650/1818-8346-2011-6-3-65-75
For citation:
Kondratovskiy P.M., Dubikov A.I., Doroshevskaya A.Y. P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis. Oncohematology. 2011;6(3):65-75. (In Russ.) https://doi.org/10.17650/1818-8346-2011-6-3-65-75
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