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Successful treatment of pancreatitis caused by L-asparaginase in clinical practice

https://doi.org/10.17650/1818-8346-2024-19-1-113-124

Abstract

Treatment intensification of acute lymphoblastic leukemia in children with L-asparaginase (L-ASP) improves therapy effectiveness and shows high survival rates. The unique biological properties of this enzyme make it possible to suppress tumor blasts proliferation by reducing blood asparagine concentration. L-ASP use is limited by toxicity and hypersensitivity reactions observed in 75 % of cases. Although most complications during L-ASP therapy are mild/moderate and are manageable with adequate accompanying therapy, the development of severe side effects leads to forced withdrawal of L-ASP, which significantly reduces the likelihood of a favorable outcome in children with acute lymphoblastic leukemia. One of the most severe toxicity manifestations is the development of asparaginase-associated pancreatitis. It worsens the prognosis and may cause patients’ death. This article presents both current data about asparaginase-associated pancreatitis and treatment experience of this complication at the Research Institute of Pediatric Oncology and Hematology of the N. N. Blokhin National Research Center of Oncology.

About the Authors

Yu. S. Korkina
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation

Timur Teymurazovich Valiev

Build. 1, 2/1 Barrikadnaya St., Moscow 125993



M. A. Shervashidze
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



T. T. Valiev
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

Build. 1, 2/1 Barrikadnaya St., Moscow 125993

24 Kashirskoe Shosse, Moscow 115522



N. A. Batmanova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



T. R. Panferova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



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Review

For citations:


Korkina Yu.S., Shervashidze M.A., Valiev T.T., Batmanova N.A., Panferova T.R. Successful treatment of pancreatitis caused by L-asparaginase in clinical practice. Oncohematology. 2024;19(1):113-124. (In Russ.) https://doi.org/10.17650/1818-8346-2024-19-1-113-124

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ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)