Minor histocompatibility antigens represented in HLA-A*02:01 and their search strategies
https://doi.org/10.17650/1818-8346-2023-18-3-115-124
Abstract
Minor histocompatibility antigens (MiHAs) are polymorphic peptides on the cell surface derived from self-proteins that are capable to induce an immune response during allogeneic hematopoietic stem cells transplantation. Their presentation occurs in the context of the certain major histocompatibility complex (HLA – human leucocyte antigen) alleles. One of the most common HLA alleles is HLA-A*02:01. Accordingly, for a significant number of donors and recipients pairs, it is possible to use the MiHAs presented in the HLA-A*02:01 as a target for relapsed leukemia therapy. This review discusses the main known MiHAs presented in the context of HLA-A*02:01, their characteristics and approaches used for identification. The described approaches may be used to search for new MiHAs for immunotherapy.
Keywords
Supporting agencies: The work was supported by the State Foundation of the Ministry of Health of Russia
About the Authors
D. S. Romanyuk
National Medical Research Center for Hematology, Ministry of Health of Russia
Russian Federation
Russian Federation
125167
4 Novyy Zykovskiy Proezd
Moscow
A. M. Pilunov
National Medical Research Center for Hematology, Ministry of Health of Russia
Russian Federation
Russian Federation
125167
4 Novyy Zykovskiy Proezd
Moscow
G. A. Efimov
Miltenyi Biotec B. V. & Co. KG
Germany
Germany
51429
Friedrich-Ebert-Straße 68
Bergisch Gladbach
A. V. Bogolyubova
National Medical Research Center for Hematology, Ministry of Health of Russia
Russian Federation
Russian Federation
Apollinariya Vasil’evna Bogolyubova
125167
4 Novyy Zykovskiy Proezd
Moscow
E. N. Parovichnikova
National Medical Research Center for Hematology, Ministry of Health of Russia
Russian Federation
Russian Federation
125167
4 Novyy Zykovskiy Proezd
Moscow
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Romanyuk D.S., Pilunov A.M., Efimov G.A., Bogolyubova A.V., Parovichnikova E.N. Minor histocompatibility antigens represented in HLA-A*02:01 and their search strategies. Oncohematology. 2023;18(3):115-124. (In Russ.) https://doi.org/10.17650/1818-8346-2023-18-3-115-124
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