Минорные антигены гистосовместимости, представляемые в HLA-А*02:01, и стратегии их поиска
https://doi.org/10.17650/1818-8346-2023-18-3-115-124
Аннотация
Минорные антигены гистосовместимости (МАГ) – полиморфные пептиды на поверхности клеток, представляющие собой фрагменты собственных белков организма, которые способны вызывать иммунный ответ при аллогенной трансплантации гемопоэтических стволовых клеток. Их презентация на поверхности клетки обусловлена присутствием определенных аллелей главного комплекса гистосовместимости (HLA – human leucocyte antigen). Одним из самых распространенных аллелей HLA является HLA-A*02:01. Соответственно, для значительного количества пар доноров и реципиентов возможно использование МАГ, представляемых в HLA-A*02:01, в качестве мишени при направленной терапии рецидивов лейкозов. В обзоре обсуждаются основные из известных МАГ, презентируемых в контексте HLA-A*02:01, их характеристики и подходы, использованные для идентификации. Описанные подходы могут применяться для поиска новых МАГ в контексте мишеней для иммунотерапии.
Ключевые слова
иммунотерапия,
минорный антиген гистосовместимости,
аллогенная трансплантация гемопоэтических стволовых клеток
При поддержке: Работа выполнена при поддержке Государственного задания Минздрава России
Об авторах
Д. С. Романюк
ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России
Россия
Россия
125167
Новый Зыковский пр-д, 4
Москва
А. М. Пилунов
ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России
Россия
Россия
125167
Новый Зыковский пр-д, 4
Москва
Г. А. Ефимов
Милтени Биотек ГмбХ
Германия
Германия
51429
ул. Фридрих-Элберт, 68
Бергиш-Гладбах
А. В. Боголюбова
ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России
Россия
Россия
Аполлинария Васильевна Боголюбова
125167
Новый Зыковский пр-д, 4
Москва
Е. Н. Паровичникова
ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России
Россия
Россия
125167
Новый Зыковский пр-д, 4
Москва
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Рецензия
Для цитирования:
Романюк Д.С., Пилунов А.М., Ефимов Г.А., Боголюбова А.В., Паровичникова Е.Н. Минорные антигены гистосовместимости, представляемые в HLA-А*02:01, и стратегии их поиска. Онкогематология. 2023;18(3):115-124. https://doi.org/10.17650/1818-8346-2023-18-3-115-124
For citation:
Romanyuk D.S., Pilunov A.M., Efimov G.A., Bogolyubova A.V., Parovichnikova E.N. Minor histocompatibility antigens represented in HLA-A*02:01 and their search strategies. Oncohematology. 2023;18(3):115-124. (In Russ.) https://doi.org/10.17650/1818-8346-2023-18-3-115-124
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