Clinical case of a 44-year-old patient with newly diagnosed peripheral T-cell lymphoma unspecified (Lennert’s lymphoma) and Loeffler’s endocarditis

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Abstract

Peripheral T-cell lymphoma unspecified (PTCLu) in most cases has an aggressive clinical course and is characterized by a high frequency of extranodal lesions. One of the manifestations of PTCLu, in particular Lennert’s lymphoma, is eosinophilia. Regardless of the development mechanism, eosinophilia can be accompanied by heart damage, leading to endomyocardial fibrosis, ventricular thrombosis and, in the final stage, to restrictive cardiomyopathies, which are manifestations of Loeffler’s endocarditis (LE). The presence of LE aggravates the course and prognosis of PTCLu, primarily limiting the possibilities of antitumor drug therapy. A multidisciplinary approach to managing a patient with PTCLu and concomitant LE makes it possible to diagnose and start both specific and cardiotropic therapy in a timely manner, ultimately improving the prognosis. A clinical case of a 44‑year-old patient with newly diagnosed PTCLu (Lennert’s lymphoma) and LE is presented.

About the authors

Yu. E. Ryabukhina

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

Author for correspondence.
Email: gemonk.yur@mail.ru
ORCID iD: 0000-0001-8443-8816

Yuliya Evgen’evna Ryabukhina

143081, Moscow region, Lapino, 1st Uspenskoe Shosse, 111

Russian Federation

O. L. Timofeeva

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0002-6229-7300

143081, Moscow region, Lapino, 1st Uspenskoe Shosse, 111

Russian Federation

A. A. Akhobekov

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0002-6395-5790

143081, Moscow region, Lapino, 1st Uspenskoe Shosse, 111

Russian Federation

P. A. Zeynalova

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0003-1564-424X

143081, Moscow region, Lapino, 1st Uspenskoe Shosse, 111
119991, Moscow, Trubetskaya St., 8, Build. 2

Russian Federation

F. M. Abbasbeyli

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0002-2359-0547

143081, Moscow region, Lapino, 1st Uspenskoe Shosse, 111

Russian Federation

G. F. Allakhverdieva

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0001-5910-5892

143081, Moscow region, Lapino, 1st Uspenskoe Shosse, 111

Russian Federation

A. G. Zhukov

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

143081, Moscow region, Lapino, 1st Uspenskoe Shosse, 111

Russian Federation

V. V. Fedotov

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies; UNIM LLC

ORCID iD: 0000-0002-9447-3292

143081, Moscow region, Lapino, 1st Uspenskoe Shosse, 111
121205, Moscow, Skolkovo Innovation Center, Bolshoy Bulvar, 42c1 office 0.049 first core

Russian Federation

L. A. Shestakova

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0002-5298-8124

143081, Moscow region, Lapino, 1st Uspenskoe Shosse, 111

Russian Federation

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