Features of acute megakaryoblastic leukemia diagnosis in a child with Down syndrome
N. K. Guskova,
O. N. Selyutina,
I. B. Lysenko,
Yu. Yu. Kozel,
O. V. Kozyuk,
V. V. Dmitrieva,
M. A. Baranenkova,
A. S. Nozdricheva https://doi.org/10.17650/1818-8346-2023-18-1-31-38
Abstract
We present a description of the difficulties in diagnosing acute megakaryoblastic leukemia in a child with Down syndrome aggravated by multiple comorbidities. In this case, a comprehensive assessment of clinical data, the results of an automatic complete blood count with a detailed interpretation of the entire range of parameters, as well as morphological and immunophenotypic bone marrow examination using an extended panel of monoclonal antibodies played a key role in the diagnosis.
About the Authors
N. K. Guskova
National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Nailya Katifovna Guskova
344037, Rostov-on-Don, 14th Liniya, 63
O. N. Selyutina
National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
344037, Rostov-on-Don, 14th Liniya, 63
I. B. Lysenko
National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
344037, Rostov-on-Don, 14th Liniya, 63
Yu. Yu. Kozel
National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
344037, Rostov-on-Don, 14th Liniya, 63
O. V. Kozyuk
National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
344037, Rostov-on-Don, 14th Liniya, 63
V. V. Dmitrieva
National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
344037, Rostov-on-Don, 14th Liniya, 63
M. A. Baranenkova
Rostov State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
344022, Rostov-on-Don, Nakhichevanskiy Pereulok, 29
A. S. Nozdricheva
National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
344037, Rostov-on-Don, 14th Liniya, 63
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Review
For citations:
Guskova N.K., Selyutina O.N., Lysenko I.B., Kozel Yu.Yu., Kozyuk O.V., Dmitrieva V.V., Baranenkova M.A., Nozdricheva A.S. Features of acute megakaryoblastic leukemia diagnosis in a child with Down syndrome. Oncohematology. 2023;18(1):31-38. (In Russ.) https://doi.org/10.17650/1818-8346-2023-18-1-31-38
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