Comparative characteristics of healthy newborns cord blood cell composition and G-SCF-mobilized blood from healthy donors
https://doi.org/10.17650/1818-8346-2009-0-4-45-50
Abstract
Cord blood cell composition is a short-lasting delivery stress consequence and is similar on adult G-CSF-mobilized peripheral blood.
G-CSF realizes biological effect by number of secondary messengers, many of which are also natural effectors of stress. In this research comparative characteristics of cell composition, including lymphocytes subpopulations, CD34+ and CD133+ cells, hematopoietic progenitor cells colony-forming activity and mobilizing cytokines concentration (IL-8, MMP-2, MMP-9), between term newborns cord blood and G-CSF-mobilized peripheral blood is shown.
Mobilized cytokines concentration ratio in combination with CD34+ cells count in cord blood and mobilized peripheral blood suggests that delivery stress possibly is not single cause of cord blood features.
About the Authors
R. Sh. Ibragimov
Federal research center of pediatric hematology, oncology and immunology
Russian Federation
Russian Federation
Moscow
E. V. Raikina
Federal research center of pediatric hematology, oncology and immunology; Moscow Stem cells bank
Russian Federation
Russian Federation
Moscow
E. Yu. Osipova
Federal research center of pediatric hematology, oncology and immunology; Moscow Stem cells bank
Russian Federation
Russian Federation
Moscow
N. N. Zimina
Moscow Center of family planning and reproduction
Russian Federation
Russian Federation
Moscow
O. A. Maiorova
Federal research center of pediatric hematology, oncology and immunology
Russian Federation
Russian Federation
Moscow
M. V. Yakovleva
Moscow Stem cells bank
Russian Federation
Russian Federation
Moscow
S. A. Roumiantsev
Federal research center of pediatric hematology, oncology and immunology; Moscow Stem cells bank
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Ibragimov R.Sh., Raikina E.V., Osipova E.Yu., Zimina N.N., Maiorova O.A., Yakovleva M.V., Roumiantsev S.A. Comparative characteristics of healthy newborns cord blood cell composition and G-SCF-mobilized blood from healthy donors. Oncohematology. 2009;(4):45-50. (In Russ.) https://doi.org/10.17650/1818-8346-2009-0-4-45-50
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