Analysis of incidence and prognostic significance  FLT3, c-KIT  and  NPM1  genes mutation in children with acute myeloid leukemia

L. V. Guk; Гук Л. В.; T. V. Savitskaya; Савицкая Т. В.; D. A. Domninsky; Домнинский Д. А.; V. O. Bobrinina; Бобрынина В. О.; M. M. Schneider; Шнейдер М. М.; A. A. Maschan; Масчан А. А.; O. V. Aleinikova; Алейникова О. В.

doi:10.17650/1818-8346-2009-0-4-27-32

Analysis of incidence and prognostic significance FLT3, c-KIT and NPM1 genes mutation in children with acute myeloid leukemia

Authors: Guk L.V.¹, Savitskaya T.V.², Domninsky D.A.¹, Bobrinina V.O.¹, Schneider M.M.¹, Maschan A.A.¹, Aleinikova O.V.²
Affiliations:
1. Federal research center of pediatric hematology, oncology and immunology
2. Republic Centre for Paediatric Oncology and Haematology
Issue: No 4 (2009)
Pages: 27-32
Section: BIOLOGY OF HEMATOLOGIC MALIGNANCIES
Published: 28.11.2009
URL: https://oncohematology.abvpress.ru/ongm/article/view/783
DOI: https://doi.org/10.17650/1818-8346-2009-0-4-27-32
ID: 783

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Abstract

Prognosis of patients with acute myeloid leukemia receiving intensive chemotherapy is defined as kariotyping anomalies, and mutations of genes responsible for surviving and self-maintenance leukemic cells. In the giving work incidence of mutation involving genes FLT3, c-KIT, NPM1 having prognostic value in adults is analysed. Kynase domain FLT3 mutation in 18 from 83 patients (21.6%) was detected. 2 from 18 patients (11%) achieved complete remission, 5 from 18 patients (27.7%) with FLT3 mutations were refractory to therapy, two patients died from treatment complications, 9 from 18 (50%) relapsed. Only 2 patients (11%) are alive in continuous complete remission. с-KIT mutations detected in 14.2% (2/14 patients), and NPM1 mutations represented allelic polymorphism. Thus, kynase domain FLT3 mutation are prognostic unfavorable.