BCR-ABL gene amplification in patients with chronic myeloid leukemia and imatinib resistance
https://doi.org/10.17650/1818-8346-2009-0-3-57-60
Abstract
The treatment of Ph-positive chronic myeloid leukemia (CML) has achieved significant progress with the tyrosine kinase inhibitor (TKI) imatinib. Complete cytogenetic remission is a standard for patients treated in chronic phase. Nevertheless, primary and acquired resistance has been observed in few CML patients. Imatinib resistance in patients is related to heterogeneous mechanisms. The role of the BCR-ABL-related mechanism of imatinib resistance —BCR-ABL gene ampliphication in primary resistant cases was studied. The BCRABL gene ampliphication was established in 18% refractory to imatinib patients. Decreasing probability of complete cytogenetic response was revealed in these cases.
About the Authors
S. I. Kutzev
Rostov state medical university
Russian Federation
Russian Federation
Rostov-on-Don
S. V. Mordanov
Rostov state medical university
Russian Federation
Russian Federation
Rostov-on-Don
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Review
For citations:
Kutzev S.I., Mordanov S.V. BCR-ABL gene amplification in patients with chronic myeloid leukemia and imatinib resistance. Oncohematology. 2009;(3):57-60. (In Russ.) https://doi.org/10.17650/1818-8346-2009-0-3-57-60
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