Influence of allogeneic mesenchymal stem cells on leukemic cells  in vitro  sensitivity to antileukemic drugs

O. S. Tatarinova; Татаринова О. С.; E. Yu. Osipova; Осипова Е. Ю.; S. A. Rumyantsev; Румянцев С. А.

Influence of allogeneic mesenchymal stem cells on leukemic cells in vitro sensitivity to antileukemic drugs

Authors: Tatarinova O.S.¹, Osipova E.Y.¹, Rumyantsev S.A.¹
Affiliations:
1. Federal Research Center of Pediatric Hematology, Oncology and Immunology
Issue: No 4 (2010)
Pages: 33-38
Section: BASIC RESEARCH
Published: 27.11.2010
URL: https://oncohematology.abvpress.ru/ongm/article/view/765
ID: 765

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Abstract

In present study influence of allogeneic bone marrow mesenchymal stem cells (MSC) on patients’ leukemic cells is investigated. Influence on in vitro sensitivity to antileukemic drugs and spontaneous and cytarabine-induced apoptosis of leukemic cells was studied. It has`been shown that MSC reduce myeloid leukemic cells sensitivity to daunorubicine. However, MSC did not statistically significant influence on spontaneous and cytarabine-induced apoptosis of leukemic cells.