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Оптимизация экспериментальных моделей заболевания лейкозом у человека (обзор литературы)

https://doi.org/10.17650/1818-8346-2012-7-4-48-52

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Аннотация

Данный обзор литературы посвящен актуальной проблеме оценки перспективности иммунотерапии, в том числе антигенспецифической клеточной терапии, при помощи животных моделей. В обзоре рассматриваются разные группы животных моделей, существующих на данный момент, и описываются методы создания этих моделей от разных линий иммунодефицитных мышей до нескольких вариантов приживления опухолевых клеток в организм животного. В обзоре затрагиваются темы возможного изучения стволовых опухолевых клеток с использованием мышиных моделей для лечения лейкоза при помощи адоптивной клеточной терапии, в том числе WT1. Затрагивается вопрос миграции, пролиферации человеческих лейкозных клеток в разных линиях мышей с разной степенью иммунодефицита. Предлагается сравнивать мышиную модель по иммунодефициту с клинической ситуацией у человека после курса химиотерапии, из этого следует оценка возможной эффективности иммунотерапии.

Об авторах

Д. Д. Панков
ФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава России Мемориальный онкологический центр им. Слоуна-Кеттеринга
Россия


А. Г. Румянцев
ФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава России
Россия


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Для цитирования:


Панков Д.Д., Румянцев А.Г. Оптимизация экспериментальных моделей заболевания лейкозом у человека (обзор литературы). Онкогематология. 2012;7(4):48-52. https://doi.org/10.17650/1818-8346-2012-7-4-48-52

For citation:


Pankov D.D., Rumyantsev A.G. Optimization of experimental human leukemia models (review). Oncohematology. 2012;7(4):48-52. (In Russ.) https://doi.org/10.17650/1818-8346-2012-7-4-48-52

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ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)