Molecular genetics monitoring of tyrosine kinase inhibitor therapy for chronic myeloid leukemia
https://doi.org/10.17650/1818-8346-2008-0-4-17-25
Abstract
Therapy for Ph-positive chronic myeloid leukemia (CML) with the tyrosine kinase inhibitor imatinib results in achievement of high hematological and cytogenetic response rates. However, most patients with a complete cytogenetic response were found to have a minimal residual disease. Therefore the role of molecular monitoring during CML therapy has recently increased. Regular molecular monitoring allows to early diagnosis of relapse and improvement of treatment outcome as a result of therapeutic intervention. For the imatinib-treated patients therapy resistance or increased BCR-ABL gene expression is an indication for kinase domain mutations testing. Detection of the mutations causing imatinib resistance is required for therapy choice. Real-time polymerase chain reaction and DNA sequencing should become customary for CML monitoring.
About the Authors
S. I. Kutsev
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
M. V. Velchenko
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
A. N. Zelzer
Rostov State Medical University
Russian Federation
Russian Federation
Rostov-on-Don
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Review
For citations:
Kutsev S.I., Velchenko M.V., Zelzer A.N. Molecular genetics monitoring of tyrosine kinase inhibitor therapy for chronic myeloid leukemia. Oncohematology. 2008;(4):17-25. (In Russ.) https://doi.org/10.17650/1818-8346-2008-0-4-17-25
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