Роль высокодозной химиотерапии с трансплантацией клеток-предшественников гемопоэза в лечении множественной миеломы
https://doi.org/10.17650/1818-8346-2008-0-4-11-16
Аннотация
В качестве терапии 2-й линии 18 больным с множественной миеломой была проведена терапия мелфаланом в дозе 200 мг/м2 с последующей трансплантацией аутологичных периферических стволовых клеток. 13 больным был проведен 1 курс высокодозной химиотерапии (ВДХТ), 5 — 2 курса. У всех пациентов до ВДХТ на фоне терапии была получена частичная ремиссия (у 15 больных ремиссия достигнута после проведения 3 курсов полихимиотерапии по схеме VAD— винкристин, доксорубицин, дексаметазон, у 3— после 3 курсов VAD и 2 курсов велкейддоксорубицин—преднизолон). Медиана времени до прогрессирования составила 33,1 (от 26 до 40) мес, общей выживаемости — 55,4 (от 29 до 40) мес.
Об авторах
С. В. Миненко
ФГУ ФНКЦ детской гематологии, онкологии и иммунологии
Россия
Россия
Москва
А. Ю. Попов
ФГУ ФНКЦ детской гематологии, онкологии и иммунологии
Россия
Россия
Москва
Н. В. Жуков
ФГУ ФНКЦ детской гематологии, онкологии и иммунологии
Россия
Россия
Москва
О. М. Вотякова
ГУ РОНЦ им. Н.Н. Блохина РАМН
Россия
Россия
Москва
В. В. Птушкин
ФГУ ФНКЦ детской гематологии, онкологии и иммунологии
Россия
Россия
Москва
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Рецензия
Для цитирования:
Миненко С.В., Попов А.Ю., Жуков Н.В., Вотякова О.М., Птушкин В.В. Роль высокодозной химиотерапии с трансплантацией клеток-предшественников гемопоэза в лечении множественной миеломы. Онкогематология. 2008;(4):11-16. https://doi.org/10.17650/1818-8346-2008-0-4-11-16
For citation:
Minenko S.V., Popov A.Yu., Zhukov N.V., Votyakova O.M., Ptushkin V.V. Role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myeloma. Oncohematology. 2008;(4):11-16. (In Russ.) https://doi.org/10.17650/1818-8346-2008-0-4-11-16
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