To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL)
https://doi.org/10.17650/1818-8346-2009-0-2-22-27
Abstract
Hodgkin lymphoma differs from anaplastic largecell lymphoma (ALCL) (≪Hodgkin-like≫ variant) by more frequent early stage diseases revealing (46%), mediastinal lymph nodes involvement (69%), softtissue components absence, small number of cases with more than one extranodal organ involvement (15%), ALK-protein absence (100%) and tumor cell B-immunophenotype (PAX 5+). Morphological features: the expressed pironinophilia in tumor cells cytoplasm by Broshe staining in systemic ALCL (T-/0 phenotype), that is rare observed in Hodgkin lymphoma; large tumor cells in systemic ALCL (_-/0 phenotype) have more polymorphic nucleuses with small nucleoluses in comparison with more spherical cells with large nucleoluses in Hodgkin lymphona; intrasinus growth observed almost in a half of cases in systemic ALCL (T-/0 phenotype) does not revealed in Hodgkin lymphoma; tumor tissue fibrosis is a rare observation in systemic ALCL (T-/0 phenotype), while fibrosis and capsule sclerosis are frequent morphological signs in Hodgkin lymphoma.
About the Authors
A. A. Semenova
Russian Academy for Postgraduate Medical Education
Russian Federation
Russian Federation
Moscow
I. V. Poddubnay
Russian Academy for Postgraduate Medical Education
Russian Federation
Russian Federation
Moscow
N. A. Probatova
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Moscow
E. A. Osmanov
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Moscow
E. N. Sorokin
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Semenova A.A., Poddubnay I.V., Probatova N.A., Osmanov E.A., Sorokin E.N. To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL). Oncohematology. 2009;(2):22-27. (In Russ.) https://doi.org/10.17650/1818-8346-2009-0-2-22-27
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