Mutation status of refractory to imatinib patients with chronic myeloid leukemia
https://doi.org/10.17650/1818-8346-2012-7-4-16-23
Abstract
Mutation status of 36 chronic myeloid leukemia (CML) patients in chronic phase with primary and secondary imatinib resistance was analyzed. BCR-ABL mutations identified by direct DNA sequencing. BCR-ABL kinase domain mutations were detected in 30.5 % (11 of 36) of those patients. Most of identified mutations were missense mutations: Q252H, M244V, G250E, Y253F/H, E255K/V, T315I, M351T, F359V, F359C, F486S. Patients with BCR-ABL mutations have significantly lower 4-year event-free survival compared with CML patients without mutations (18 % vs. 53 %; р = 0.003). The results can be used as reference information in deciding on therapy in imatinib resistant CML patients with clinically relevant BCR-ABL mutations.
About the Authors
E. G. Ovsyannikova
Astrakhan State Medical Academy
Russian Federation
Russian Federation
K. D. Kaplanov
Volgograd Regional Clinical Oncological Dispensary № 1
Russian Federation
Russian Federation
T. Yu. Klitochenko
Volgograd Regional Clinical Oncological Dispensary № 1
Russian Federation
Russian Federation
A. V. Misyurin
LLC «GenoTehnologiya»
Russian Federation
Russian Federation
I. L. Davydkin
Research Institute of Hematology, Transfusiology and Intensive Care, Samara State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
L. V. Zaklyakova
Astrakhan State Medical Academy
Russian Federation
Russian Federation
E. A. Popov
Astrakhan State Medical Academy
Russian Federation
Russian Federation
B. N. Levitan
Astrakhan State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Ovsyannikova E.G., Kaplanov K.D., Klitochenko T.Yu., Misyurin A.V., Davydkin I.L., Zaklyakova L.V., Popov E.A., Levitan B.N. Mutation status of refractory to imatinib patients with chronic myeloid leukemia. Oncohematology. 2012;7(4):16-23. (In Russ.) https://doi.org/10.17650/1818-8346-2012-7-4-16-23
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