Хронический миелолейкоз — до и после применения иматиниба (Часть I)
https://doi.org/10.17650/1818-8346-2009-0-2-4-16
Аннотация
Первый успешный опыт проведения эффективной таргетной терапии был достигнут при применении иматиниба в лечении хронического миелолейкоза (ХМЛ). Заболевание, ранее считавшееся практически некурабельным, в настоящее время поддается вполне успешному контролю с помощью малотоксичной консервативной терапии. На фоне лечения ингибиторами тирозинкиназ у большинства пациентов с ХМЛ возможно достижение стабильной клинико-гематологической и цитогенетической ремиссии, а у части из них лейкемические клетки не удается обнаружить и с помощью самых чувствительных молекулярных методов исследования. В I части статьи отражены данные литературы по патогенезу ХМЛ, современным критериям фаз и групп риска развития болезни, а также роли препаратов интерферона-альфа и аллотрансплантации гемопоэтических стволовых клеток в эру иматиниба и новых ингибиторов тирозинкиназ.
Об авторах
Е. Г. Ломаиа
ФГУ Федеральный центр сердца, крови и эндокринологии им. В. А. Алмазова
Россия
Россия
Санкт-Петербург
Д. В. Моторин
ФГУ Федеральный центр сердца, крови и эндокринологии им. В. А. Алмазова
Россия
Россия
Санкт-Петербург
Е. Г. Романова
ФГУ Федеральный центр сердца, крови и эндокринологии им. В. А. Алмазова
Россия
Россия
Санкт-Петербург
А. Ю. Зарицкий
ФГУ Федеральный центр сердца, крови и эндокринологии им. В. А. Алмазова; Петербургский государственный медицинский университет им. И. П. Павлова
Россия
Россия
Санкт-Петербург
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Рецензия
Для цитирования:
Ломаиа Е.Г., Моторин Д.В., Романова Е.Г., Зарицкий А.Ю. Хронический миелолейкоз — до и после применения иматиниба (Часть I). Онкогематология. 2009;(2):4-16. https://doi.org/10.17650/1818-8346-2009-0-2-4-16
For citation:
Lomaia E.G., Motorin D.V., Romanova E.G., Zaritzkiy A.Yu. Chronic myeloid leukemia — before and after imatinib (First part). Oncohematology. 2009;(2):4-16. (In Russ.) https://doi.org/10.17650/1818-8346-2009-0-2-4-16
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