Meningeal involvement in chronic lymphocytic leukemia
https://doi.org/10.17650/1818-8346-2007-0-4-89-90
Abstract
Despite chronic lymphocytic leukemia (CLL) is the most frequent type of leukemia and more than hundred years has passed from the moment of the first description of its clinical picture, the problem on nervous system involvement remains unresolved because of this kind of lesion remains _ very rarely sign of disease. There are less then ten case reports according to literary data. We observed just a one patient with CLL and diagnosed meningeal involvement at the hematologic department of Regional clinical hospital for more than thirty-year period. Clinical and laboratory symptoms were successfully treated by intrathecal administration of cytostatic agents.
About the Authors
S. N. Menshakova
Regional clinical hospital
Russian Federation
Russian Federation
Tver
I. V. Medvedeva
Tver State medical academy
Russian Federation
Russian Federation
References
1. Воробьев А.И. Руководство по гематологии. М., Ньюдиамед; 2003. Т. 2. с. 69—82.
2. Lane P.K., Townsend R.M., Corash L. Central nervous system involvement in a patient with chronic lymphocytic leukemia and non-Hodgkin's lymphoma (Richter's syndrome), with concordant cell surface immunoglobulin isotypic and immunophenotypic markers. Am J Clin Pathol 1988;89(2):254—9.
3. Wang M.L., Shih L.Y., Dunn P., Kuo M.C. Meningeal involvement in B-cell chronic lymphocytic leukemia: report of two cases. J Formos Med Assoc 2000;99(10):775—8.
4. Akinota-Ogunremi O., Whitney C., Mathur S.C., Finch C.N. Chronic lymphocytic leukemia presenting symptomatic central nervous system involvement. Ann Hematol 2002;81(7):402—4.
5. Brick W.G., Majmundar M., Hendricks L.K. et al. Leukemic lep-tomeningeal involvement in stage 0 and stage 1 chronic lymphocytic leukemia. Leuk Lymphoma 2002;43(1):199—201.
6. Kaiser U. Cerebral involvement as the initial manifestation of chronic lymphocytic leukaemia. Acta Haematol 2003;109(4):193—5.
7. Watanabe N., Takahashi T., Sugimoto N. et al. Excellent response of chemotherapy-resistant B-cell-type chronic lymphocytic leukemia with meningeal involvement to rit-uximab. Int J Clin Oncol 2005;10(5):357—61.
8. Marmont A.M. Leukemic meningitis in B-cell chronoc lymphocytic leukemia: resolution following intrathecal methotrexate. Blood 2000;96(2):776—7.
9. Vogt-Schaden M., Wildemann B., Stelljes M. et al. Leptomeningeal dissemination of chronic lymphocytic leukemia. Molecular genetic detection in cerebrospinal fluid. Nervenarzt 1999;70(4):363—7.
10. Cramer S.C., Glaspy J.A., Efird J.T., Louis D.N. Chronic lymphocytic leukemia and central nervous system: a clinical and pathological study. Neurology 1996;46(1):19—25.
Review
For citations:
Menshakova S.N., Medvedeva I.V. Meningeal involvement in chronic lymphocytic leukemia. Oncohematology. 2007;(4):89-90. (In Russ.) https://doi.org/10.17650/1818-8346-2007-0-4-89-90
Views:
546
Email this article 