Ex vivo экспансия гемопоэтических стволовых клеток пуповинной крови (обзор литературы)
https://doi.org/10.17650/1818-8346-2012-7-1-35-45
Аннотация
Пуповинная кровь (ПК) в настоящее время является привлекательным источником гемопоэтических стволовых клеток (ГСК) для трансплантации в детской практике и у взрослых пациентов с различными злокачественными и незлокачественными заболеваниями. Однако ее применение в клинике ограничено низким количеством клеток в трансплантате, что коррелирует с отсроченным приживлением, удлинением времени до восстановления тромбоцитов и нейтрофилов, развитием инфекционных осложнений. Для решения этой проблемы было предпринято несколько попыток, одна из которых – получение достаточного количества гемопоэтических клеток-предшественников путем ex vivo экспансии. В данной статье проведен обзор литературы, посвященный особенностям экспансии ГСК ПК.
Об авторах
Т. В. Шаманская
ФГБУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздравсоцразвития России
Россия
Россия
Е. Ю. Осипова
ФГБУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздравсоцразвития России
Россия
Россия
С. А. Румянцев
ФГБУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздравсоцразвития России
Россия
Россия
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Рецензия
Для цитирования:
Шаманская Т.В., Осипова Е.Ю., Румянцев С.А. Ex vivo экспансия гемопоэтических стволовых клеток пуповинной крови (обзор литературы). Онкогематология. 2012;7(1):35-45. https://doi.org/10.17650/1818-8346-2012-7-1-35-45
For citation:
Shamanskaya T.V., Osipova E.Yu., Roumiantsev S.A. Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review). Oncohematology. 2012;7(1):35-45. (In Russ.) https://doi.org/10.17650/1818-8346-2012-7-1-35-45
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