First research of use Vero-Fludarabine in chronic lymphocytic leukemia and non-hodgkins lymphoma
https://doi.org/10.17650/1818-8346-2007-0-4-73-78
Abstract
The aim of the investigation was to estimate Vero-Fludarabine in chronic lymphocytic leukemia and non-Hodgkin’s lymphoma patients. We report the activity of three combinations of Vero-Fludarabine, one with cyclophosphamide (Vero-FluCy), the second with cyclophosphamide plus rubida (Vero-FLUCYr) and 3rd with rituximab (VeroFCR). For patients with chronic lymphocytic leukemia who received Vero-FluCy the overall response rate was 66.6%. Of the 9 patients, who received Vero-FluCy, 33.3% achieved complete remission and 33.3% partial remission. For patients with follicular lymphoma grades 1 and 2 who received Vero-FLUCYr or VeroFCR the overall response rate was 100%. The treatment was well tolerated. Hematologic toxicity included neutropenia and thrombocytopenia. 24% patients who received Vero-FluCy were complicated by infections. Nonhematologic toxicity was mild.
We conclude that Vero-Fludarabine is an effective treatment in previously untreated or in pretreated patients with chronic lymphocytic leukemia and follicular lymphomas.
About the Authors
S. S. Bessmeltsev
Russian Research Institute of Hematology and Transfusiology
Russian Federation
Russian Federation
K. M. Abdulkadyrov
Russian Research Institute of Hematology and Transfusiology
Russian Federation
Russian Federation
St.-Petersburg
References
1. Клиническая онкогематология: Руководство для врачей. Под ред. М.А. Волковой. М.; 2001.
2. Волкова М.А. Полвека в терапии хронического лимфолейкоза. Гематол итрансфузиол 1998;(5):6—11.
3. Czuczman M.S., Fallon A., Mohr A. et al. Rituximab in combination with CHOP or fludarabine in low-grade lymphoma. Semin Oncol 2002;29 (Suppl 2):36—40.
4. Абдулкадыров К.М., Самускевич И.Г., Бессмельцев С.С. и др. Диагностика и лечение больных неходжкинскими лимфомами низкой степени злокачественности. Пособие для врачей. С.-Пб.; 2000.
5. Поддубная И.В. Обоснование лечебной тактики при неходжкинских лимфомах. Соврем онкол 2002;(1):3—7.
6. Vargo F., Demeter J. Progress in treatment of non-Hodgkin's lymphomas. Magy Onkol 2001;45:45—50.
7. Liso V., Molica S., Capalbo S. et al. Response to fludarabine in B-cell chronic lymphocytic leukemia patients previously treated with chlorambucil as up-front therapy and a CHOP-like regimen as second line therapy. Haematologica 2001;86:1165—71.
8. Бессмельцев С.С. Флударабин в терапии больных хроническим лимфолейкозом. Медицина 2006;(4):92—101.
9. Абдулкадыров К.М., Бессмельцев С.С., Самускевич И.Г. Медицинская технология: Современные методы лечения больных неходжкинскими злокачественными лимфомами. С.-Пб.; 2007.
10. Tothova E., Kafkova A., Fricova M. et al. Fludarabine combined with cyclophosphamid is highly effective in the treatment of chronic lymphocytic leukemia. Neoplasma 2003;50:433—7.
11. Harris N., Jaffe E., Diebold J. et al. The World Health Organization Classification of neoplastic disease of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997. Commentary. Ann Oncol 1999;10:1419—32.
12. Бессмельцев С.С., Абдулкадыров К.М. Эффективность флударабина при неходжкинских лимфомах. Вестн гематол 2005;3: 18—25.
13. Diehl V., Specht L., Pfistner B. et al. Response criteria in malignant lymphomas revisitet - a proposal of the international harmonization project of the German competence network of malignant lymphomas. In: Hematology. Education program of the 11th congress of the European Hematology Association. Amsterdam, June 15—18 2006. p. 151—3.
14. Eichhorst B.F., Busch R., Hopfinger G. et al. Fludarabine plus cyclophosphamide versus fludarabine alone in first line therapy of younger patients with chronic lymphocytic leukemia. Blood 2006;107:885—91.
15. Tsimberidou A.M., Keating M.J., Giles FJ. et al. Fludarabine and mitox-antrone for patients with chronic lymphocytic leukemia. Cancer 2004:100: 2583—91.
16. Бессмельцев С.С., Абдулкадыров К.М. Возможности флударабина в терапии больных неходжкинскими лимфомами. Укр журн гематол та трансфузюл 2004;(4):5—14.
17. Wilder D.D., Ogden J.L., Jain V.K. Efficacy of fludarabine/mitoxantrone/ dexamethasone alternating with CHOP in bulky follicular non-Hodgkin’s lymphoma. Clin Lymphoma 2002;2:229—37.
Review
For citations:
Bessmeltsev S.S., Abdulkadyrov K.M. First research of use Vero-Fludarabine in chronic lymphocytic leukemia and non-hodgkins lymphoma. Oncohematology. 2007;(4):73-78. (In Russ.) https://doi.org/10.17650/1818-8346-2007-0-4-73-78
Views:
151
Email this article 