Modern treatment programs for primary Hodgkin's lymphoma and reasons of treatment failure

Abstract

Between 1975 and 2005, 566patients (pts) with primary Hodgkin s lymphoma were treated at N.N. Blokhin Cancer Research Center. We analyzed an influence of treatment programs execution on long-term results based on data of treatment efficacy. Median follow-up period was 58 months (range 5 months — 25 years). Deviations of treatment program were registered in 28,6% of pts in cases of execution of full treatment program at Cancer Research Center. The main part of treatment program was performed at Cancer Research Center and the minority of chemotherapy courses was accomplished domiciliary (40,4% pts). In cases of pts examination, choice of therapy and start of treatment at Cancer Research Center, execution of the main part of course was accomplished domiciliary (63,5% pts).

Even increase for more than 6 weeks of the only one interval significantly resulted to reduction of long-term treatment effect. We observed statistically significant decreased of long-term treatment effect in case of reduction the chemotherapy dimension (dose reduction) to 1/3 from predesigned regimen though after achievement of complete remission as well as cancellation of radiotherapy in combined treatment after achievement of complete remission. All deviations indicated above were revealed in 38,8% pts. An exact adherence to modern treatment programs for pts with Hodgkin's lymphoma facilitate to increase effectiveness of therapy.