Acute non-lymphoblastic leukemia: characteristics of cytogenetic anomalies and their influence on clinical course of the disease

Abstract

Cytogenetic changes in bone marrow cells and their influence on clinical course of the disease were analyzed in 106 patients with acute non-lymphoblastic leukemia (ANLL). According to rearrangements of chromosomes the patients were divided into three groups. The first group consisted of patients with anomalies of karyotype typical for particular variants of ANLL. The second group comprised patients with chromosome anomalies, which are not associated with any special variant of disease. The third group included patients with unique rearrangements of chromosomes characterized by special mechanism of formation of karyotype changes. Overall, three patients with complex karyotype anomalies formed the third group: first patient with 46, Y,t(2;15)(q37;p13),+12,add(13)(q14),add(13)(21), second patient with 42, XX, -4, t(6;17)(p25;q25), -8, -15, i(17q),-18, +mar/ 44, XX, -4, t(6;17)(p25;q25), -15, i(17q),-18, ++mar[2]/ 44, XX, -4, t(6;17)(p25;q25), -15, i(17q),-18, +mar, + min/ 46, XX, -4, t(6;17)(p25;q25), del(8)(q21), -15, i(17q), -18, +mar[4]/44, XX, -3, t(6;17)(p25;q25), -15, i(17q),-18,+ mar, + min, and third patient with 51, XY, t(12;18)(p13;p11.3), +8, +10,-14, der17,+ mar[5]. Among peculiar features of - t(2;15)(q37;p13), t(6;17)(p25;q25), t(12;18) rearrangements were the primary character of translocations between these chromosomes, and participation of whole chromosomes, but not their fragments, in the formation of translocations.