A rare case of an anaphylactic reaction to plasma and recombinant blood coagulation factor VIII in a child with severe hemophilia A

A rare case of anaphylactic shock after administration of 4^th generation recombinant blood coagulation factor VIII is presented. Anaphylactic shock is a life-threatening complication for a patient with hemophilia A. Temporarily refrain from re-administration of factor VIII, a skin test confirming drug choice, and a patient desensitization procedure provide the clinician with a chance to continue hemostatic replacement therapy for a patient with hemophilia A.
The main purpose of this case report is to determine the algorithm of actions to overcome the consequences of anaphylactic shock and continue the prophylactic administration of coagulation factor VIII concentrate to prevent bleeding in a child with a rare random combination of an anaphylactic reaction and congenital coagulation disorders.