Роль микробиома в патогенезе инфекционного и иммунологического повреждения желудочно-кишечного тракта у детей с онкогематологическими заболеваниями
https://doi.org/10.17650/1818-8346-2021-16-2-86-93
Аннотация
Инфекционные осложнения остаются одной из наиболее значимых проблем, ассоциированных с противоопухолевой терапией у онкологических пациентов. В результате проводимой цитотоксической, лучевой, а также антибактериальной терапии возникают дисбиоз и повреждение слизистого барьера желудочно-кишечного тракта. Эти изменения приводят к развитию мукозита, тем самым повышая риск эндогенной транслокации микрофлоры с последующим вероятным развитием тяжелых инфекционно-воспалительных заболеваний. Кроме этого, существующие на сегодняшний день данные свидетельствуют о наличии взаимосвязи между нарушениями в кишечном микробиоме и развитием посттрансплантационной реакции «трансплантат против хозяина». В статье приведены существующие парадигмы в отношении определения роли функционального состояния желудочно-кишечного тракта у онкологических пациентов в целях оптимизации подходов к профилактике и противомикробному лечению.
Ключевые слова
Об авторах
Д. А. Моргачева
ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия
Россия
Дарья Андреевна Моргачева
197341 Санкт-Петербург, ул. Аккуратова, 2
Ю. В. Диникина
ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия
Россия
197341 Санкт-Петербург, ул. Аккуратова, 2
Ю. К. Тошина
ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия
Россия
197341 Санкт-Петербург, ул. Аккуратова, 2
М. Б. Белогурова
ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия
Россия
197341 Санкт-Петербург, ул. Аккуратова, 2
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Рецензия
Для цитирования:
Моргачева Д.А., Диникина Ю.В., Тошина Ю.К., Белогурова М.Б. Роль микробиома в патогенезе инфекционного и иммунологического повреждения желудочно-кишечного тракта у детей с онкогематологическими заболеваниями. Онкогематология. 2021;16(2):86-93. https://doi.org/10.17650/1818-8346-2021-16-2-86-93
For citation:
Morgacheva D.A., Dinikina Yu.V., Toshina Yu.K., Belogurova M.B. The microbiome role in pathogenesis of inflammatory and immune alterations of gastrointestinal tract in pediatric patients with cancer. Oncohematology. 2021;16(2):86-93. (In Russ.) https://doi.org/10.17650/1818-8346-2021-16-2-86-93
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