Second tumors in children with hematological malignancies
https://doi.org/10.17650/1818-8346-2021-16-1-36-46
Abstract
Background. Hemoblastoses treatment success in children made it possible to cure the vast majority of patients. The follow-up period exceeds tens of years, during which the problem of second tumors (ST) becomes urgent. The objective of the study was to characterize ST in patients who underwent a malignant tumor of hematopoietic and lymphoid tissues at the age of 0 to 18 years.
Materials and methods. The study included 64 patients with ST development in the period from 1 to 38 years.
Results. Most frequently ST developed after treatment of Hodgkin's lymphoma (45.3 %) and acute lymphoblastic leukemia (35.9 %), supported by high cumulative doses of alkylating agents and radiation therapy. Among STs, in 35.9 % of cases, thyroid cancer was diagnosed, in 10.9 % - acute leukemia, in 9.4 % - tumors of the central nervous system. The results of ST treatment are significantly worse than those of primary tumors. Thus, of 64 patients with ST, 46 (71.9 %) are alive, death from ST progression was noted in 18 (28.1 %) cases.
Conclusion. Improvement of modern treatment protocols aimed at reducing the indications for radiation therapy and cumulative doses of alkylating agents, along with the development of effective follow-up programs for children cured of hematological malignancies, will probably help reduce the ST incidence.
About the Authors
N. A. Susuleva
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Build. 1, 2 / 1 Barrikadnaya St., Moscow 125993; 24 Kashirskoe Shosse, Moscow 115478.
T. T. Valiev
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Timur Teymurazovich Valiev.
Build. 1, 2 / 1 Barrikadnaya St., Moscow 125993; 24 Kashirskoe Shosse, Moscow 115478.
N. S. Martynova
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Build. 1, 2 / 1 Barrikadnaya St., Moscow 125993; 24 Kashirskoe Shosse, Moscow 115478.
S. N. Mikhaylova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478.
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For citations:
Susuleva N.A., Valiev T.T., Martynova N.S., Mikhaylova S.N. Second tumors in children with hematological malignancies. Oncohematology. 2021;16(1):36-46. (In Russ.) https://doi.org/10.17650/1818-8346-2021-16-1-36-46
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