Раково-тестикулярный антиген MAGE-C1 / CT7 при множественной миеломе: обзор литературы
Аннотация
Группа опухолеассоциированных антигенов, экспрессия которых в норме описана в плацентарных клетках и зародышевых клетках яичка, получила название «раково-тестикулярные антигены». В настоящее время идентифицировано более 40 семейств генов, кодирующих раково-тестикулярные антигены, и их экспрессия изучена при многих типах злокачественных заболеваний. Предполагается, что экспрессия раково-тестикулярных антигенов может способствовать развитию процесса опухолевой трансформации, в том числе и при гематологических заболеваниях. Особый интерес в патогенезе множественной миеломы представляет антиген MAGE-C1/СT7, экспрессия которого наиболее часто выявляется при данном заболевании. Согласно опубликованным данным экспрессия MAGE-C1/СT7 при множественной миеломе может выступать в качестве дополнительного маркера неблагоприятного прогноза заболевания, отражать эффективность химиотерапевтических подходов и, возможно, являться более ранним предиктором рецидива или прогрессии.
Об авторе
Э. А. Макунина
ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России
Россия
Россия
Элеонора Анатольевна Макунина
125167 Москва, Новый Зыковский проезд, 4
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Для цитирования:
Макунина Э.А. Раково-тестикулярный антиген MAGE-C1 / CT7 при множественной миеломе: обзор литературы. Онкогематология. 2020;15(4):29-37. https://doi.org/10.17650/1818-8346-2020-15-4-29-37
For citation:
Makunina E.A. Cancer-testis antigen MAGE-C1/ CT7 in multiple myeloma: literature review. Oncohematology. 2020;15(4):29-37. (In Russ.) https://doi.org/10.17650/1818-8346-2020-15-4-29-37
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