Unspecified skin peripheral T-cell lymphoma: diagnostic difficulties
https://doi.org/10.17650/1818-8346-2020-15-3-63-66
Abstract
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) have an aggressive, life-threatening course. 5‑year survival rate is less than 20 %, which may be due to not timely diagnosis. PTCL-NOS can histologically and immunophenotypically mimic other T-cell lymphomas of the skin, including mycosis fungoides. In this connection, the correct diagnosis is most often established in the late stages of the disease. We present a clinical case of PTCL-NOS misdiagnosed as mycosis fungoides.
About the Authors
O. Yu. OlisovaRussian Federation
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia
E. Yu. Vertieva
Russian Federation
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia
D. R. Amshinskaya
Russian Federation
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia
M. G. Lecaillon
Russian Federation
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia
E. V. Grekova
Russian Federation
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia
References
1. Doronin V.A. T-cell lymphomas: therapeutic possibilities for a limited choice. Klinicheskaya onkogematologiya. Fundamental’nye issledovaniya i klinicheskaya praktika = Clinical Hematology Oncology. Basic Research and Clinical Practice 2013;6(2):127–38. (In Russ.).
2. Tolkachjov S.N., Weenig R.H., Comfere N.I. Cutaneous peripheral T-cell lymphoma, not otherwise specified: a single-center prognostic analysis. J Am Acad Dermatol 2016;75(5):992–9. DOI: 10.1016/j.jaad.2016.06.011.
3. Singh A., Bhagat M., Siddiqui A.D., Thapa S.S. Peripheral T-cell lymphoma, not otherwise specified: an unusual presentation of a rare lymphoma. Cureus 2019;11(1):e3813. DOI: 10.7759/cureus.3813.
4. Willemze R., Cerroni L., Kempf W. et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood 2019;133(16):1703–14. DOI: 10.1182/blood-2018-11-881268.
5. Aderhold K., Carpenter L., Brown K., Donato A. Primary cutaneous peripheral T-cell lymphoma not otherwise specified: a rapidly progressive variant of cutaneous T-cell lymphoma. Case Rep Oncol Med 2015;2015:429068. DOI: 10.1155/2015/429068.
6. Kempf W., Rozati S., Kerl K. et al. Cutaneous peripheral T-cell lymphomas, unspecified/NOS and rare subtypes: a heterogeneous group of challenging cutaneous lymphomas. G Ital Dermatol Venereol 2012;147(6):553–62.
7. Moskowitz A.J., Lunning M.A., Horwitz S.M. How I treat the peripheral T-Cell lymphomas. Blood 2014;123(17):2636–44. DOI: 10.1182/Blood-2013-12-516245.
8. Dearden C.E., Johnson R., Pettengell R. et al. Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma). Br J Haematol 2011;153(4):451–85. DOI: 10.1111/j.1365-2141.2011.08651.x.
Review
For citations:
Olisova O.Yu., Vertieva E.Yu., Amshinskaya D.R., Lecaillon M.G., Grekova E.V. Unspecified skin peripheral T-cell lymphoma: diagnostic difficulties. Oncohematology. 2020;15(3):63-66. (In Russ.) https://doi.org/10.17650/1818-8346-2020-15-3-63-66